Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars
<i>Helicobacter pylori</i> infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/15/5690 |
| _version_ | 1797586294039117824 |
|---|---|
| author | Bartłomiej Piasecki Izabela Korona-Głowniak Anna Kiełtyka-Dadasiewicz Agnieszka Ludwiczuk |
| author_facet | Bartłomiej Piasecki Izabela Korona-Głowniak Anna Kiełtyka-Dadasiewicz Agnieszka Ludwiczuk |
| author_sort | Bartłomiej Piasecki |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to which many strains are now resistant. <i>Mentha</i> species have been used as a natural treatment for gastrointestinal diseases throughout history and essential oils (EOs) derived from these plants show promising results as potential antimicrobial agents. In this study, EOs obtained from the leaves and flowers of five cultivars of <i>Mentha</i> × <i>piperita</i> and <i>M. spicata</i> were examined by GC-MS. The investigated mints are representatives of four chemotypes: the menthol chemotype (<i>M.</i> × <i>piperita</i> ‘Multimentha’ and <i>M.</i> × <i>piperita</i> ‘Swiss’), the piperitenone oxide chemotype (<i>M.</i> × <i>piperita</i> ‘Almira’), the linalool chemotype (<i>M.</i> × <i>piperita</i> ‘Granada’), and the carvone chemotype (<i>M. spicata</i> ‘Moroccan’). The chemical composition of EOs from mint flowers and leaves was comparable with the exception of the Swiss cultivar. Menthol was the most abundant component in the leaves while menthone was highest in flowers. The <i>H. pylori</i> ATCC 43504 reference strain and 10 other <i>H. pylori</i> clinical strains were examined for their sensitivity to the EOs in addition to their major monoterpenoid components (menthol, menthone, carvone, dihydrocarvone, linalool, 1,8-cineole, and limonene). All tested mint EOs showed inhibitory activity against both the reference <i>H. pylori</i> ATCC 43504 strain (MIC 15.6–31.3 mg/L) and clinical <i>H. pylori</i> strains (MIC<sub>50/90</sub> 31.3–250 mg/L/62.5–500 mg/L). Among the reference monoterpenes, menthol (MIC<sub>50/90</sub> 7.8/31.3 mg/L) and carvone (MIC<sub>50/90</sub> 31.3/62.5 mg/L) had the highest anti-<i>H. pylori</i> activity, which also correlated with a higher activity of EOs containing these compounds (<i>M.</i> × <i>piperita</i> ‘Swiss’ and <i>M. spicata</i> ‘Moroccan’). A synergistic and additive interaction between the most active EOs/compounds and antibiotics possibly points to a new plant-based anti-<i>H. pylori</i> treatment. |
| first_indexed | 2024-03-11T00:21:17Z |
| format | Article |
| id | doaj.art-2854d3f4849248f889a7a5d6893ecef7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:21:17Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2854d3f4849248f889a7a5d6893ecef72023-11-18T23:17:35ZengMDPI AGMolecules1420-30492023-07-012815569010.3390/molecules28155690Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> CultivarsBartłomiej Piasecki0Izabela Korona-Głowniak1Anna Kiełtyka-Dadasiewicz2Agnieszka Ludwiczuk3Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, PolandDepartment of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, PolandDepartment of Plant Production Technology and Commodity, University of Life Sciences in Lublin, 20-950 Lublin, PolandDepartment of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland<i>Helicobacter pylori</i> infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to which many strains are now resistant. <i>Mentha</i> species have been used as a natural treatment for gastrointestinal diseases throughout history and essential oils (EOs) derived from these plants show promising results as potential antimicrobial agents. In this study, EOs obtained from the leaves and flowers of five cultivars of <i>Mentha</i> × <i>piperita</i> and <i>M. spicata</i> were examined by GC-MS. The investigated mints are representatives of four chemotypes: the menthol chemotype (<i>M.</i> × <i>piperita</i> ‘Multimentha’ and <i>M.</i> × <i>piperita</i> ‘Swiss’), the piperitenone oxide chemotype (<i>M.</i> × <i>piperita</i> ‘Almira’), the linalool chemotype (<i>M.</i> × <i>piperita</i> ‘Granada’), and the carvone chemotype (<i>M. spicata</i> ‘Moroccan’). The chemical composition of EOs from mint flowers and leaves was comparable with the exception of the Swiss cultivar. Menthol was the most abundant component in the leaves while menthone was highest in flowers. The <i>H. pylori</i> ATCC 43504 reference strain and 10 other <i>H. pylori</i> clinical strains were examined for their sensitivity to the EOs in addition to their major monoterpenoid components (menthol, menthone, carvone, dihydrocarvone, linalool, 1,8-cineole, and limonene). All tested mint EOs showed inhibitory activity against both the reference <i>H. pylori</i> ATCC 43504 strain (MIC 15.6–31.3 mg/L) and clinical <i>H. pylori</i> strains (MIC<sub>50/90</sub> 31.3–250 mg/L/62.5–500 mg/L). Among the reference monoterpenes, menthol (MIC<sub>50/90</sub> 7.8/31.3 mg/L) and carvone (MIC<sub>50/90</sub> 31.3/62.5 mg/L) had the highest anti-<i>H. pylori</i> activity, which also correlated with a higher activity of EOs containing these compounds (<i>M.</i> × <i>piperita</i> ‘Swiss’ and <i>M. spicata</i> ‘Moroccan’). A synergistic and additive interaction between the most active EOs/compounds and antibiotics possibly points to a new plant-based anti-<i>H. pylori</i> treatment.https://www.mdpi.com/1420-3049/28/15/5690mint chemotypesmentholcarvone<i>Helicobacter pylori</i> |
| spellingShingle | Bartłomiej Piasecki Izabela Korona-Głowniak Anna Kiełtyka-Dadasiewicz Agnieszka Ludwiczuk Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars Molecules mint chemotypes menthol carvone <i>Helicobacter pylori</i> |
| title | Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars |
| title_full | Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars |
| title_fullStr | Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars |
| title_full_unstemmed | Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars |
| title_short | Composition and Anti-<i>Helicobacter pylori</i> Properties of Essential Oils Obtained from Selected <i>Mentha</i> Cultivars |
| title_sort | composition and anti i helicobacter pylori i properties of essential oils obtained from selected i mentha i cultivars |
| topic | mint chemotypes menthol carvone <i>Helicobacter pylori</i> |
| url | https://www.mdpi.com/1420-3049/28/15/5690 |
| work_keys_str_mv | AT bartłomiejpiasecki compositionandantiihelicobacterpyloriipropertiesofessentialoilsobtainedfromselectedimenthaicultivars AT izabelakoronagłowniak compositionandantiihelicobacterpyloriipropertiesofessentialoilsobtainedfromselectedimenthaicultivars AT annakiełtykadadasiewicz compositionandantiihelicobacterpyloriipropertiesofessentialoilsobtainedfromselectedimenthaicultivars AT agnieszkaludwiczuk compositionandantiihelicobacterpyloriipropertiesofessentialoilsobtainedfromselectedimenthaicultivars |