Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms

Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms

DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunolog...

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Bibliographic Details
Main Authors: Federico D’Alessio, Lucia Lione, Erika Salvatori, Federica Bucci, Alessia Muzi, Giuseppe Roscilli, Mirco Compagnone, Eleonora Pinto, Gianfranco Battistuzzi, Antonella Conforti, Luigi Aurisicchio, Fabio Palombo
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Vaccines
Subjects:
COVID-19
DNA stability
immune responses
vaccines
Online Access:https://www.mdpi.com/2076-393X/11/3/678

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