The right time for senescence
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cel...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-11-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/72449 |
| _version_ | 1811199657797222400 |
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| author | Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde |
| author_facet | Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde |
| author_sort | Diogo Paramos-de-Carvalho |
| collection | DOAJ |
| description | Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field. |
| first_indexed | 2024-04-12T01:51:15Z |
| format | Article |
| id | doaj.art-28587e67f11245f4ba9f5d67b7f05e29 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:51:15Z |
| publishDate | 2021-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-28587e67f11245f4ba9f5d67b7f05e292022-12-22T03:52:55ZengeLife Sciences Publications LtdeLife2050-084X2021-11-011010.7554/eLife.72449The right time for senescenceDiogo Paramos-de-Carvalho0https://orcid.org/0000-0003-2274-7167Antonio Jacinto1https://orcid.org/0000-0002-4193-6089Leonor Saúde2https://orcid.org/0000-0001-5933-8872Instituto de Medicina Molecular – João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, PortugalCEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, PortugalInstituto de Medicina Molecular – João Lobo Antunes e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, PortugalCellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.https://elifesciences.org/articles/72449senescencetimetissue remodellingpathophysiologysenotherapies |
| spellingShingle | Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde The right time for senescence eLife senescence time tissue remodelling pathophysiology senotherapies |
| title | The right time for senescence |
| title_full | The right time for senescence |
| title_fullStr | The right time for senescence |
| title_full_unstemmed | The right time for senescence |
| title_short | The right time for senescence |
| title_sort | right time for senescence |
| topic | senescence time tissue remodelling pathophysiology senotherapies |
| url | https://elifesciences.org/articles/72449 |
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