Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study
Objective High cholesterol level is a risk factor for coronary artery disease, and coronary artery disease is a major risk factor for out-of-hospital cardiac arrest (OHCA). However, the effect of cholesterol level on outcomes of OHCA has been poorly studied. This study aimed to determine the effect...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Emergency Medicine
2019-09-01
|
| Series: | Clinical and Experimental Emergency Medicine |
| Subjects: | |
| Online Access: | http://www.ceemjournal.org/upload/pdf/ceem-18-057.pdf |
| _version_ | 1797895601535320064 |
|---|---|
| author | Jong Hwan Kim Dae Han Wi Jun Hee Lee Hyung Jun Song Sang Do Shin Young Sun Ro Kwang-Ho Bae |
| author_facet | Jong Hwan Kim Dae Han Wi Jun Hee Lee Hyung Jun Song Sang Do Shin Young Sun Ro Kwang-Ho Bae |
| author_sort | Jong Hwan Kim |
| collection | DOAJ |
| description | Objective High cholesterol level is a risk factor for coronary artery disease, and coronary artery disease is a major risk factor for out-of-hospital cardiac arrest (OHCA). However, the effect of cholesterol level on outcomes of OHCA has been poorly studied. This study aimed to determine the effect of cholesterol level on outcomes of OHCA. Methods This cross-sectional study used the CAPTURES (Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance) project database in Korea. Multivariable conditional logistic regression analysis was performed to estimate the effect of cholesterol level on outcomes in OHCA. Results In all, 584 cases of OHCA were analyzed; those with cholesterol levels <120 mg/dL were classified as having low total cholesterol (TC) (n=197), those with levels ranging from 120–199 mg/dL as middle TC (n=322), and those with ≥200 mg/dL as high TC (n=65). Compared to low TC, more patients with middle TC and high TC survived to discharge (9.1% vs. 22.0% and 26.2%, respectively, P=0.001). The good cerebral performance category also increased in that order (4.1 % vs. 14.6% and 23.1%, respectively, P≤0.001). Comparing middle TC and high TC with low TC, adjusted odds ratios (95% confidence intervals) were 1.97 (1.06 to 3.64) and 2.53 (1.08 to 5.92) for survival to discharge, respectively, and 2.53 (1.07 to 5.98) and 4.73 (1.63 to 13.71) for good neurological recovery, respectively. Conclusion Higher cholesterol is associated with better outcomes in OHCA; cholesterol level is a good predictor of outcomes of OHCA. |
| first_indexed | 2024-04-10T07:28:26Z |
| format | Article |
| id | doaj.art-285d4b8117dd4a719126816ee503a8a7 |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:28:26Z |
| publishDate | 2019-09-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-285d4b8117dd4a719126816ee503a8a72023-02-24T04:12:48ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252019-09-016324224910.15441/ceem.18.057244Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional studyJong Hwan Kim0Dae Han Wi1Jun Hee Lee2Hyung Jun Song3Sang Do Shin4Young Sun Ro5Kwang-Ho Bae6 Department of Emergency Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea Department of Emergency Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea Department of Emergency Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea Department of Emergency Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea Department of Emergency Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea Mibyeong Research Center, Korea Institute of Oriental Medicine, Daejeon, KoreaObjective High cholesterol level is a risk factor for coronary artery disease, and coronary artery disease is a major risk factor for out-of-hospital cardiac arrest (OHCA). However, the effect of cholesterol level on outcomes of OHCA has been poorly studied. This study aimed to determine the effect of cholesterol level on outcomes of OHCA. Methods This cross-sectional study used the CAPTURES (Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance) project database in Korea. Multivariable conditional logistic regression analysis was performed to estimate the effect of cholesterol level on outcomes in OHCA. Results In all, 584 cases of OHCA were analyzed; those with cholesterol levels <120 mg/dL were classified as having low total cholesterol (TC) (n=197), those with levels ranging from 120–199 mg/dL as middle TC (n=322), and those with ≥200 mg/dL as high TC (n=65). Compared to low TC, more patients with middle TC and high TC survived to discharge (9.1% vs. 22.0% and 26.2%, respectively, P=0.001). The good cerebral performance category also increased in that order (4.1 % vs. 14.6% and 23.1%, respectively, P≤0.001). Comparing middle TC and high TC with low TC, adjusted odds ratios (95% confidence intervals) were 1.97 (1.06 to 3.64) and 2.53 (1.08 to 5.92) for survival to discharge, respectively, and 2.53 (1.07 to 5.98) and 4.73 (1.63 to 13.71) for good neurological recovery, respectively. Conclusion Higher cholesterol is associated with better outcomes in OHCA; cholesterol level is a good predictor of outcomes of OHCA.http://www.ceemjournal.org/upload/pdf/ceem-18-057.pdfheart arrestcholesteroloutcomecardiac arrest pursuit trial with unique registration and epidemiologic surveillance |
| spellingShingle | Jong Hwan Kim Dae Han Wi Jun Hee Lee Hyung Jun Song Sang Do Shin Young Sun Ro Kwang-Ho Bae Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study Clinical and Experimental Emergency Medicine heart arrest cholesterol outcome cardiac arrest pursuit trial with unique registration and epidemiologic surveillance |
| title | Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study |
| title_full | Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study |
| title_fullStr | Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study |
| title_full_unstemmed | Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study |
| title_short | Effects of cholesterol levels on outcomes of out-of-hospital cardiac arrest: a cross-sectional study |
| title_sort | effects of cholesterol levels on outcomes of out of hospital cardiac arrest a cross sectional study |
| topic | heart arrest cholesterol outcome cardiac arrest pursuit trial with unique registration and epidemiologic surveillance |
| url | http://www.ceemjournal.org/upload/pdf/ceem-18-057.pdf |
| work_keys_str_mv | AT jonghwankim effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT daehanwi effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT junheelee effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT hyungjunsong effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT sangdoshin effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT youngsunro effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy AT kwanghobae effectsofcholesterollevelsonoutcomesofoutofhospitalcardiacarrestacrosssectionalstudy |