Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on t...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9766 |
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| author | Andreas Seidel Corinna L. Seidel Matthias Weider Rüdiger Junker Lina Gölz Helga Schmetzer |
| author_facet | Andreas Seidel Corinna L. Seidel Matthias Weider Rüdiger Junker Lina Gölz Helga Schmetzer |
| author_sort | Andreas Seidel |
| collection | DOAJ |
| description | Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988–2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health. |
| first_indexed | 2024-03-10T13:52:56Z |
| format | Article |
| id | doaj.art-285dcb43c4594096998265ecfb7f0adb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:52:56Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-285dcb43c4594096998265ecfb7f0adb2023-11-21T01:55:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124976610.3390/ijms21249766Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current LiteratureAndreas Seidel0Corinna L. Seidel1Matthias Weider2Rüdiger Junker3Lina Gölz4Helga Schmetzer5Dental Practice, Bahnhofstraße 10, 82223 Eichenau, GermanyDepartment of Orthodontics and Orofacial Orthopedics, Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Glückstr. 11, 91054 Erlangen, GermanyDepartment of Orthodontics and Orofacial Orthopedics, Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Glückstr. 11, 91054 Erlangen, GermanyCenter for Dental Prosthetics and Biomaterials, Danube Private University Krems, Steiner Landstraße 124, 3500 Krems-Stein, AustriaDepartment of Orthodontics and Orofacial Orthopedics, Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Glückstr. 11, 91054 Erlangen, GermanyDepartment of Medical III, University Hospital LMU Munich, Marchioninistraße 15, 81377 Munich, GermanyNatural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988–2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health.https://www.mdpi.com/1422-0067/21/24/9766natural killer cellsnatural killer T cellsperiodontitishost defenseinnate immunityadaptive immunity |
| spellingShingle | Andreas Seidel Corinna L. Seidel Matthias Weider Rüdiger Junker Lina Gölz Helga Schmetzer Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature International Journal of Molecular Sciences natural killer cells natural killer T cells periodontitis host defense innate immunity adaptive immunity |
| title | Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature |
| title_full | Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature |
| title_fullStr | Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature |
| title_full_unstemmed | Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature |
| title_short | Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature |
| title_sort | influence of natural killer cells and natural killer t cells on periodontal disease a systematic review of the current literature |
| topic | natural killer cells natural killer T cells periodontitis host defense innate immunity adaptive immunity |
| url | https://www.mdpi.com/1422-0067/21/24/9766 |
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