Iron in Neurodegeneration – Cause or Consequence?
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions. Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron overload in the basal ganglia. High iron levels and iron related pathogenic triggers have also been implicated in sporadic neurod...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2019-03-01
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Series: | Frontiers in Neuroscience |
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Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00180/full |
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author | Alain Ndayisaba Christine Kaindlstorfer Gregor K. Wenning |
author_facet | Alain Ndayisaba Christine Kaindlstorfer Gregor K. Wenning |
author_sort | Alain Ndayisaba |
collection | DOAJ |
description | Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions. Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron overload in the basal ganglia. High iron levels and iron related pathogenic triggers have also been implicated in sporadic neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Iron-induced dyshomeostasis within vulnerable brain regions is still insufficiently understood. Here, we summarize the modes of action by which iron might act as primary or secondary disease trigger in neurodegenerative disorders. In addition, available treatment options targeting brain iron dysregulation and the use of iron as biomarker in prodromal stages are critically discussed to address the question of cause or consequence. |
first_indexed | 2024-12-22T17:41:14Z |
format | Article |
id | doaj.art-285e60ef5c924aca81917ac6fb3222c2 |
institution | Directory Open Access Journal |
issn | 1662-453X |
language | English |
last_indexed | 2024-12-22T17:41:14Z |
publishDate | 2019-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Neuroscience |
spelling | doaj.art-285e60ef5c924aca81917ac6fb3222c22022-12-21T18:18:24ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-03-011310.3389/fnins.2019.00180435242Iron in Neurodegeneration – Cause or Consequence?Alain NdayisabaChristine KaindlstorferGregor K. WenningIron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions. Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron overload in the basal ganglia. High iron levels and iron related pathogenic triggers have also been implicated in sporadic neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Iron-induced dyshomeostasis within vulnerable brain regions is still insufficiently understood. Here, we summarize the modes of action by which iron might act as primary or secondary disease trigger in neurodegenerative disorders. In addition, available treatment options targeting brain iron dysregulation and the use of iron as biomarker in prodromal stages are critically discussed to address the question of cause or consequence.https://www.frontiersin.org/article/10.3389/fnins.2019.00180/fullironneurodegenerationneurodegenerative mechanismsmitochondrial dysfunctionautophagic-lysosomal dysfunctionprotein aggregation |
spellingShingle | Alain Ndayisaba Christine Kaindlstorfer Gregor K. Wenning Iron in Neurodegeneration – Cause or Consequence? Frontiers in Neuroscience iron neurodegeneration neurodegenerative mechanisms mitochondrial dysfunction autophagic-lysosomal dysfunction protein aggregation |
title | Iron in Neurodegeneration – Cause or Consequence? |
title_full | Iron in Neurodegeneration – Cause or Consequence? |
title_fullStr | Iron in Neurodegeneration – Cause or Consequence? |
title_full_unstemmed | Iron in Neurodegeneration – Cause or Consequence? |
title_short | Iron in Neurodegeneration – Cause or Consequence? |
title_sort | iron in neurodegeneration cause or consequence |
topic | iron neurodegeneration neurodegenerative mechanisms mitochondrial dysfunction autophagic-lysosomal dysfunction protein aggregation |
url | https://www.frontiersin.org/article/10.3389/fnins.2019.00180/full |
work_keys_str_mv | AT alainndayisaba ironinneurodegenerationcauseorconsequence AT christinekaindlstorfer ironinneurodegenerationcauseorconsequence AT gregorkwenning ironinneurodegenerationcauseorconsequence |