Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00675-5 |
| _version_ | 1818681526693396480 |
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| author | Yu-Ting Lin Chien-Chung Chen Chiung-Chun Huang Katsuhiko Nishimori Kuei-Sen Hsu |
| author_facet | Yu-Ting Lin Chien-Chung Chen Chiung-Chun Huang Katsuhiko Nishimori Kuei-Sen Hsu |
| author_sort | Yu-Ting Lin |
| collection | DOAJ |
| description | Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner. |
| first_indexed | 2024-12-17T10:04:21Z |
| format | Article |
| id | doaj.art-28605a40fc4e460f9dc10d9d07344dc1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:04:21Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-28605a40fc4e460f9dc10d9d07344dc12022-12-21T21:53:12ZengNature PortfolioNature Communications2041-17232017-09-018111610.1038/s41467-017-00675-5Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neuronsYu-Ting Lin0Chien-Chung Chen1Chiung-Chun Huang2Katsuhiko Nishimori3Kuei-Sen Hsu4Department of Pharmacology, College of Medicine, National Cheng Kung UniversityDepartment of Pharmacology, College of Medicine, National Cheng Kung UniversityDepartment of Pharmacology, College of Medicine, National Cheng Kung UniversityDepartment of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku UniversityDepartment of Pharmacology, College of Medicine, National Cheng Kung UniversityOxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner.https://doi.org/10.1038/s41467-017-00675-5 |
| spellingShingle | Yu-Ting Lin Chien-Chung Chen Chiung-Chun Huang Katsuhiko Nishimori Kuei-Sen Hsu Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons Nature Communications |
| title | Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons |
| title_full | Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons |
| title_fullStr | Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons |
| title_full_unstemmed | Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons |
| title_short | Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons |
| title_sort | oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in ca3 pyramidal neurons |
| url | https://doi.org/10.1038/s41467-017-00675-5 |
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