Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections

Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections

Abstract Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have recently attracted attention as an alternative approach to injected cell suspensions for stem cell therapy. However, cell engraftment and cytokine expression levels between hUC-MSC sheets and their cell susp...

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Bibliographic Details
Main Authors: Mitsuyoshi Nakao, Makoto Matsui, Kyungsook Kim, Nobuhiro Nishiyama, David W. Grainger, Teruo Okano, Hideko Kanazawa, Kenichi Nagase
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Cell sheet transplantation
Cytokine expression
Engraftment
Temperature-responsive cell cultureware
Cell retention
Online Access:https://doi.org/10.1186/s13287-023-03593-0

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