Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity an...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-021-01770-6 |
| _version_ | 1818742463131549696 |
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| author | Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu |
| author_facet | Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu |
| author_sort | Chun-Mei Feng |
| collection | DOAJ |
| description | Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study. Methods All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II. Results Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively. Conclusions Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients. |
| first_indexed | 2024-12-18T02:12:55Z |
| format | Article |
| id | doaj.art-2861514c82a04ae0bc008f80a1f5e49f |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-18T02:12:55Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-2861514c82a04ae0bc008f80a1f5e49f2022-12-21T21:24:26ZengBMCBMC Pulmonary Medicine1471-24662021-12-0121111010.1186/s12890-021-01770-6Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort studyChun-Mei Feng0Xin-Ming Wang1Meng-Die Li2Zheng Xu3Dong-Xu Hua4Jia-Yi Cheng5Ling Zheng6Hui Zhao7Lin Fu8Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityDepartment of Pharmacy, First Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityRespiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical UniversityAbstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study. Methods All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II. Results Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively. Conclusions Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients.https://doi.org/10.1186/s12890-021-01770-6Community-acquired pneumoniaInterleukin-17CAP severity scoresPrognosisBiomarker |
| spellingShingle | Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study BMC Pulmonary Medicine Community-acquired pneumonia Interleukin-17 CAP severity scores Prognosis Biomarker |
| title | Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study |
| title_full | Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study |
| title_fullStr | Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study |
| title_full_unstemmed | Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study |
| title_short | Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study |
| title_sort | serum interleukin 17 predicts severity and prognosis in patients with community acquired pneumonia a prospective cohort study |
| topic | Community-acquired pneumonia Interleukin-17 CAP severity scores Prognosis Biomarker |
| url | https://doi.org/10.1186/s12890-021-01770-6 |
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