CRISPR/Cas9 nanoeditor of double knockout large fragments of E6 and E7 oncogenes for reversing drugs resistance in cervical cancer

CRISPR/Cas9 nanoeditor of double knockout large fragments of E6 and E7 oncogenes for reversing drugs resistance in cervical cancer

Abstract Drug resistance of tumor cells is always a headache problem in clinical treatment. In order to combat chemotherapy-resistance in cervical cancer and improve treatment effect, we design a CRISPR/Cas9 nanoeditor to knock out two key oncogenes E6 and E7 that lead to drug tolerance. Meanwhile,...

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Bibliographic Details
Main Authors: Xianhuang Li, Mingming Guo, Bei Hou, Bin Zheng, Zhiyun Wang, Mengqian Huang, Yanan Xu, Jin Chang, Tao Wang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Nanobiotechnology
Subjects:
Drug resistance
CRISPR/Cas9
Nanoeditor
Oncogene deletion
Cervical cancer
Online Access:https://doi.org/10.1186/s12951-021-00970-w

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