A liquid immunogenic fiducial eluter for image-guided radiotherapy
IntroductionFiducials are routinely used to provide image-guidance during radiotherapy. Here, a new nanoparticle-based liquid immunogenic fiducial is investigated for its potential to provide image-guidance, while also enhancing treatment outcomes.MethodsThis fiducial, liquid immunogenic fiducial el...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1020088/full |
| _version_ | 1811195392429129728 |
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| author | Michele Moreau Michele Moreau Michele Moreau Geraud Richards Sayeda Yasmin-Karim Amol Narang Curtiland Deville Wilfred Ngwa Wilfred Ngwa Wilfred Ngwa |
| author_facet | Michele Moreau Michele Moreau Michele Moreau Geraud Richards Sayeda Yasmin-Karim Amol Narang Curtiland Deville Wilfred Ngwa Wilfred Ngwa Wilfred Ngwa |
| author_sort | Michele Moreau |
| collection | DOAJ |
| description | IntroductionFiducials are routinely used to provide image-guidance during radiotherapy. Here, a new nanoparticle-based liquid immunogenic fiducial is investigated for its potential to provide image-guidance, while also enhancing treatment outcomes.MethodsThis fiducial, liquid immunogenic fiducial eluter (LIFE) biomaterial, is formulated with natural biodegradable polymers, chitosan and sodium alginate with radio-sensitizing nanoparticles, and immunoadjuvant like anti-CD40 monoclonal antibody. Once administered intra-tumorally, this liquid smart radiotherapy biomaterial congeals within the calcium rich tumor microenvironment. The potential use of LIFE biomaterial for providing image guidance in magnetic resonance imaging (MRI) and computed tomography (CT) was investigated over different time period in a pre-clinical tumored mouse model.ResultsResults showed that the LIFE biomaterial can provide both MRI contrast and CT imaging contrast over 3-weeks, with gradual decrease of the contrast over time, as the LIFE biomaterial biodegrades. Results also showed the LIFE biomaterial significantly slowed tumor growth and prolonged mice survival (p < 0.0001) over time.DiscussionThe results highlight the potential use of the LIFE biomaterial as a multi-functional smart radiotherapy biomaterial that could be developed and optimized for hypo-fractionated radiotherapy applications and combining radiotherapy with immunoadjuvants. |
| first_indexed | 2024-04-12T00:42:33Z |
| format | Article |
| id | doaj.art-2861bdb599a74a649439b259b8e1f73f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T00:42:33Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2861bdb599a74a649439b259b8e1f73f2022-12-22T03:54:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10200881020088A liquid immunogenic fiducial eluter for image-guided radiotherapyMichele Moreau0Michele Moreau1Michele Moreau2Geraud Richards3Sayeda Yasmin-Karim4Amol Narang5Curtiland Deville6Wilfred Ngwa7Wilfred Ngwa8Wilfred Ngwa9Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesDepartment of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesIntroductionFiducials are routinely used to provide image-guidance during radiotherapy. Here, a new nanoparticle-based liquid immunogenic fiducial is investigated for its potential to provide image-guidance, while also enhancing treatment outcomes.MethodsThis fiducial, liquid immunogenic fiducial eluter (LIFE) biomaterial, is formulated with natural biodegradable polymers, chitosan and sodium alginate with radio-sensitizing nanoparticles, and immunoadjuvant like anti-CD40 monoclonal antibody. Once administered intra-tumorally, this liquid smart radiotherapy biomaterial congeals within the calcium rich tumor microenvironment. The potential use of LIFE biomaterial for providing image guidance in magnetic resonance imaging (MRI) and computed tomography (CT) was investigated over different time period in a pre-clinical tumored mouse model.ResultsResults showed that the LIFE biomaterial can provide both MRI contrast and CT imaging contrast over 3-weeks, with gradual decrease of the contrast over time, as the LIFE biomaterial biodegrades. Results also showed the LIFE biomaterial significantly slowed tumor growth and prolonged mice survival (p < 0.0001) over time.DiscussionThe results highlight the potential use of the LIFE biomaterial as a multi-functional smart radiotherapy biomaterial that could be developed and optimized for hypo-fractionated radiotherapy applications and combining radiotherapy with immunoadjuvants.https://www.frontiersin.org/articles/10.3389/fonc.2022.1020088/fullnanoparticlessmart radiotherapy biomaterialsbiodegradable polymersimmunoadjuvantradiation therapyliquid fiducials |
| spellingShingle | Michele Moreau Michele Moreau Michele Moreau Geraud Richards Sayeda Yasmin-Karim Amol Narang Curtiland Deville Wilfred Ngwa Wilfred Ngwa Wilfred Ngwa A liquid immunogenic fiducial eluter for image-guided radiotherapy Frontiers in Oncology nanoparticles smart radiotherapy biomaterials biodegradable polymers immunoadjuvant radiation therapy liquid fiducials |
| title | A liquid immunogenic fiducial eluter for image-guided radiotherapy |
| title_full | A liquid immunogenic fiducial eluter for image-guided radiotherapy |
| title_fullStr | A liquid immunogenic fiducial eluter for image-guided radiotherapy |
| title_full_unstemmed | A liquid immunogenic fiducial eluter for image-guided radiotherapy |
| title_short | A liquid immunogenic fiducial eluter for image-guided radiotherapy |
| title_sort | liquid immunogenic fiducial eluter for image guided radiotherapy |
| topic | nanoparticles smart radiotherapy biomaterials biodegradable polymers immunoadjuvant radiation therapy liquid fiducials |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1020088/full |
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