Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480
The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (<b>1</b>) and B (<b>2</b>), togeth...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/7/339 |
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| author | Ling-Hong Meng Xiao-Ming Li Hong-Lei Li Bin-Gui Wang |
| author_facet | Ling-Hong Meng Xiao-Ming Li Hong-Lei Li Bin-Gui Wang |
| author_sort | Ling-Hong Meng |
| collection | DOAJ |
| description | The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (<b>1</b>) and B (<b>2</b>), together with three known sesquiterpenoids, sesquicaranoic acid B (<b>3</b>), cyclonerodiol (<b>4</b>) and bisabol-l-on-13-säuremethylester (<b>5</b>), were characterized from a co-culture of the marine-derived fungal isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound <b>1</b> represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher’s method and electronic circular dichroism (ECD) calculations. Compound <b>1</b> showed potent inhibitory activities against <i>Ceratobasidium cornigerum</i> and <i>Edwardsiella tarda</i>. |
| first_indexed | 2024-03-10T18:50:06Z |
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| id | doaj.art-286259b4c85b4b1cb3875d164dbe71de |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T18:50:06Z |
| publishDate | 2020-06-01 |
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| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-286259b4c85b4b1cb3875d164dbe71de2023-11-20T05:10:18ZengMDPI AGMarine Drugs1660-33972020-06-0118733910.3390/md18070339Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480Ling-Hong Meng0Xiao-Ming Li1Hong-Lei Li2Bin-Gui Wang3Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaThe co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (<b>1</b>) and B (<b>2</b>), together with three known sesquiterpenoids, sesquicaranoic acid B (<b>3</b>), cyclonerodiol (<b>4</b>) and bisabol-l-on-13-säuremethylester (<b>5</b>), were characterized from a co-culture of the marine-derived fungal isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound <b>1</b> represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher’s method and electronic circular dichroism (ECD) calculations. Compound <b>1</b> showed potent inhibitory activities against <i>Ceratobasidium cornigerum</i> and <i>Edwardsiella tarda</i>.https://www.mdpi.com/1660-3397/18/7/339<i>Penicillium chermesinum</i><i>Penicillium bilaiae</i>co-culturesecondary metabolitesantimicrobial activity |
| spellingShingle | Ling-Hong Meng Xiao-Ming Li Hong-Lei Li Bin-Gui Wang Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 Marine Drugs <i>Penicillium chermesinum</i> <i>Penicillium bilaiae</i> co-culture secondary metabolites antimicrobial activity |
| title | Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 |
| title_full | Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 |
| title_fullStr | Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 |
| title_full_unstemmed | Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 |
| title_short | Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of <i>Penicillium bilaiae</i> MA-267 and <i>Penicillium chermesinum</i> EN-480 |
| title_sort | chermebilaenes a and b new bioactive meroterpenoids from co cultures of marine derived isolates of i penicillium bilaiae i ma 267 and i penicillium chermesinum i en 480 |
| topic | <i>Penicillium chermesinum</i> <i>Penicillium bilaiae</i> co-culture secondary metabolites antimicrobial activity |
| url | https://www.mdpi.com/1660-3397/18/7/339 |
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