Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy
Abstract This cross-sectional study aimed to quantitatively analyze the optical coherence tomography angiography (OCTA) images using MATLAB-based software and evaluate the initial changes in macular vascular density and the distortion of the foveal avascular zone (FAZ), before the clinical appearanc...
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| Format: | Article |
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BMC
2022-06-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02492-x |
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| author | Mehrdad Afarid Negar Mohsenipoor Hossein Parsaei Yalda Amirmoezzi Mohsen Ghofrani-Jahromi Peyman Jafari Aliakbar Mohsenipour Fatemeh Sanie-Jahromi |
| author_facet | Mehrdad Afarid Negar Mohsenipoor Hossein Parsaei Yalda Amirmoezzi Mohsen Ghofrani-Jahromi Peyman Jafari Aliakbar Mohsenipour Fatemeh Sanie-Jahromi |
| author_sort | Mehrdad Afarid |
| collection | DOAJ |
| description | Abstract This cross-sectional study aimed to quantitatively analyze the optical coherence tomography angiography (OCTA) images using MATLAB-based software and evaluate the initial changes in macular vascular density and the distortion of the foveal avascular zone (FAZ), before the clinical appearance of diabetic retinopathy. For this purpose, 21 diabetic patients without any clinical features indicating DR, and 21 healthy individuals matched with patients based on their demographic characteristics were included. Macular thickness, macular vascular density, and morphological changes of FAZ were assessed using OCTA. The diagnostic ability of morphological parameters was evaluated by receiver operating curve analysis. The intraclass correlation coefficient (ICCC) index was used to check the consistency of the extracted values. There was no significant difference in age, gender, LogMAR visual acuity, spherical equivalent, and intra-ocular pressure amongst patients and controls. No correlation was found between age and the FAZ area as well as vascular density. The vascular structure of the superficial layer showed FAZ enlargement, reduced vascular density in the macular area, and significant deviations of FAZ shape parameters (convexity and Frequency Domain Irregularity) in patients compared with healthy individuals. Measurements were highly correlated between separate imaging sessions with ICCC of over 0.85 for all parameters. The represented data suggests that radiomics parameters can be applied as both an early screening tool and guidance for better follow-up of diabetic patients who have not had any sign of DR in fundoscopic exams. |
| first_indexed | 2024-04-13T15:28:37Z |
| format | Article |
| id | doaj.art-2864bb0947e84ea3af35dc3c811fa192 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T15:28:37Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-2864bb0947e84ea3af35dc3c811fa1922022-12-22T02:41:27ZengBMCBMC Ophthalmology1471-24152022-06-012211910.1186/s12886-022-02492-xAssessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathyMehrdad Afarid0Negar Mohsenipoor1Hossein Parsaei2Yalda Amirmoezzi3Mohsen Ghofrani-Jahromi4Peyman Jafari5Aliakbar Mohsenipour6Fatemeh Sanie-Jahromi7Poostchi Ophthalmology Research Center, department of ophthalmology, Shiraz University of Medical SciencesDepartment of ophthalmology, Medical school, Shiraz University of Medical SciencesDepartment of Medical Physics and Engineering, Shiraz University of Medical SciencesDepartment of Medical Physics and Engineering, Shiraz University of Medical SciencesDepartment of Medical Physics and Engineering, Shiraz University of Medical SciencesDepartment of Biostatistics, Faculty of Medicine, Shiraz University of Medical SciencesDepartment of Statistical and Actuarial Sciences, University of Western Ontario, London Health Sciences CentrePoostchi Ophthalmology Research Center, department of ophthalmology, Shiraz University of Medical SciencesAbstract This cross-sectional study aimed to quantitatively analyze the optical coherence tomography angiography (OCTA) images using MATLAB-based software and evaluate the initial changes in macular vascular density and the distortion of the foveal avascular zone (FAZ), before the clinical appearance of diabetic retinopathy. For this purpose, 21 diabetic patients without any clinical features indicating DR, and 21 healthy individuals matched with patients based on their demographic characteristics were included. Macular thickness, macular vascular density, and morphological changes of FAZ were assessed using OCTA. The diagnostic ability of morphological parameters was evaluated by receiver operating curve analysis. The intraclass correlation coefficient (ICCC) index was used to check the consistency of the extracted values. There was no significant difference in age, gender, LogMAR visual acuity, spherical equivalent, and intra-ocular pressure amongst patients and controls. No correlation was found between age and the FAZ area as well as vascular density. The vascular structure of the superficial layer showed FAZ enlargement, reduced vascular density in the macular area, and significant deviations of FAZ shape parameters (convexity and Frequency Domain Irregularity) in patients compared with healthy individuals. Measurements were highly correlated between separate imaging sessions with ICCC of over 0.85 for all parameters. The represented data suggests that radiomics parameters can be applied as both an early screening tool and guidance for better follow-up of diabetic patients who have not had any sign of DR in fundoscopic exams.https://doi.org/10.1186/s12886-022-02492-xDiabetes Mellitus (DM)Optical Coherence Tomography Angiography (OCTA)Retinal vascular analysisFoveal avascular zoneDiabetic retinopathy |
| spellingShingle | Mehrdad Afarid Negar Mohsenipoor Hossein Parsaei Yalda Amirmoezzi Mohsen Ghofrani-Jahromi Peyman Jafari Aliakbar Mohsenipour Fatemeh Sanie-Jahromi Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy BMC Ophthalmology Diabetes Mellitus (DM) Optical Coherence Tomography Angiography (OCTA) Retinal vascular analysis Foveal avascular zone Diabetic retinopathy |
| title | Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy |
| title_full | Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy |
| title_fullStr | Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy |
| title_full_unstemmed | Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy |
| title_short | Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy |
| title_sort | assessment of macular findings by oct angiography in patients without clinical signs of diabetic retinopathy radiomics features for early screening of diabetic retinopathy |
| topic | Diabetes Mellitus (DM) Optical Coherence Tomography Angiography (OCTA) Retinal vascular analysis Foveal avascular zone Diabetic retinopathy |
| url | https://doi.org/10.1186/s12886-022-02492-x |
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