B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis

B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis

Immunoglobulin M (IgM) to oxidation specific epitopes (OSE) are inversely associated with atherosclerosis in mice and humans. The B-1b subtype of B-1 cells secrete IgM to OSE, and unlike B-1a cells, are capable of long-lasting IgM memory. What attributes make B-1b cells different than B-1a cells is...

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Bibliographic Details
Main Authors: Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
B-1 cells
IgM antibodies
IgHV sequencing
aging
CCR6
atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.909475/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.909475/full

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