Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators
Neuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cutic...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2016-12-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/19686 |
| _version_ | 1811200672857587712 |
|---|---|
| author | Wilson Mena Sören Diegelmann Christian Wegener John Ewer |
| author_facet | Wilson Mena Sören Diegelmann Christian Wegener John Ewer |
| author_sort | Wilson Mena |
| collection | DOAJ |
| description | Neuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cuticle at the end of every molt. Ecdysis is triggered by ETH (Ecdysis triggering hormone), and we show that the response of peptidergic neurons that produce CCAP (crustacean cardioactive peptide), which are key targets of ETH and control the onset of ecdysis behavior, depends fundamentally on the actions of neuropeptides produced by other direct targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; and by inhibitory actions mediated by GABA. Our findings provide insights into how this critical insect behavior is controlled and general principles for understanding how neuropeptides organize neuronal activity and behaviors. |
| first_indexed | 2024-04-12T02:07:35Z |
| format | Article |
| id | doaj.art-286614d875ae43a19555fc89a2727611 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:07:35Z |
| publishDate | 2016-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-286614d875ae43a19555fc89a27276112022-12-22T03:52:29ZengeLife Sciences Publications LtdeLife2050-084X2016-12-01510.7554/eLife.19686Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulatorsWilson Mena0Sören Diegelmann1Christian Wegener2https://orcid.org/0000-0003-4481-3567John Ewer3https://orcid.org/0000-0002-6806-3628Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaiso, Valparaiso, ChileTheodor-Boveri-Institute, University of Würzburg, Würzburg, GermanyTheodor-Boveri-Institute, University of Würzburg, Würzburg, GermanyCentro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaiso, Valparaiso, ChileNeuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cuticle at the end of every molt. Ecdysis is triggered by ETH (Ecdysis triggering hormone), and we show that the response of peptidergic neurons that produce CCAP (crustacean cardioactive peptide), which are key targets of ETH and control the onset of ecdysis behavior, depends fundamentally on the actions of neuropeptides produced by other direct targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; and by inhibitory actions mediated by GABA. Our findings provide insights into how this critical insect behavior is controlled and general principles for understanding how neuropeptides organize neuronal activity and behaviors.https://elifesciences.org/articles/19686neuropeptidesneurohormoneecdysismolteclosion hormoneecdysis triggering hormone |
| spellingShingle | Wilson Mena Sören Diegelmann Christian Wegener John Ewer Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators eLife neuropeptides neurohormone ecdysis molt eclosion hormone ecdysis triggering hormone |
| title | Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| title_full | Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| title_fullStr | Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| title_full_unstemmed | Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| title_short | Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| title_sort | stereotyped responses of drosophila peptidergic neuronal ensemble depend on downstream neuromodulators |
| topic | neuropeptides neurohormone ecdysis molt eclosion hormone ecdysis triggering hormone |
| url | https://elifesciences.org/articles/19686 |
| work_keys_str_mv | AT wilsonmena stereotypedresponsesofdrosophilapeptidergicneuronalensembledependondownstreamneuromodulators AT sorendiegelmann stereotypedresponsesofdrosophilapeptidergicneuronalensembledependondownstreamneuromodulators AT christianwegener stereotypedresponsesofdrosophilapeptidergicneuronalensembledependondownstreamneuromodulators AT johnewer stereotypedresponsesofdrosophilapeptidergicneuronalensembledependondownstreamneuromodulators |