Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder
Exploring the disruptions to intrinsic resting-state networks (RSNs) in schizophrenia-spectrum disorders yields a better understanding of the disease-specific pathophysiology. However, our knowledge of the neurobiological underpinnings of schizotypal personality disorders mostly relies on research o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/312 |
| _version_ | 1797410944777715712 |
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| author | Ji-Won Hur Taekwan Kim Kang Ik K. Cho Jun Soo Kwon |
| author_facet | Ji-Won Hur Taekwan Kim Kang Ik K. Cho Jun Soo Kwon |
| author_sort | Ji-Won Hur |
| collection | DOAJ |
| description | Exploring the disruptions to intrinsic resting-state networks (RSNs) in schizophrenia-spectrum disorders yields a better understanding of the disease-specific pathophysiology. However, our knowledge of the neurobiological underpinnings of schizotypal personality disorders mostly relies on research on schizotypy or schizophrenia. This study aimed to investigate the RSN abnormalities of schizotypal personality disorder (SPD) and their clinical implications. Using resting-state data, the intra- and inter-network of the higher-order functional networks (default mode network, DMN; frontoparietal network, FPN; dorsal attention network, DAN; salience network, SN) were explored in 22 medication-free, community-dwelling, non-help seeking individuals diagnosed with SPD and 30 control individuals. Consequently, while there were no group differences in intra-network functional connectivity across DMN, FPN, DAN, and SN, the SPD participants exhibited attenuated anticorrelation between the right frontal eye field region of the DAN and the right posterior parietal cortex region of the FPN. The decreases in anticorrelation were correlated with increased cognitive–perceptual deficits and disorganization factors of the schizotypal personality questionnaire, as well as reduced independence–performance of the social functioning scale for all participants together. This study, which links SPD pathology and social functioning deficits, is the first evidence of impaired large-scale intrinsic brain networks in SPD. |
| first_indexed | 2024-03-09T04:37:50Z |
| format | Article |
| id | doaj.art-286a89f599f7498e9ccc46adf2af90e0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:37:50Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-286a89f599f7498e9ccc46adf2af90e02023-12-03T13:25:18ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110231210.3390/jcm10020312Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality DisorderJi-Won Hur0Taekwan Kim1Kang Ik K. Cho2Jun Soo Kwon3Department of Psychology, Korea University, Seoul 02841, KoreaDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, KoreaDepartment of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USADepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, KoreaExploring the disruptions to intrinsic resting-state networks (RSNs) in schizophrenia-spectrum disorders yields a better understanding of the disease-specific pathophysiology. However, our knowledge of the neurobiological underpinnings of schizotypal personality disorders mostly relies on research on schizotypy or schizophrenia. This study aimed to investigate the RSN abnormalities of schizotypal personality disorder (SPD) and their clinical implications. Using resting-state data, the intra- and inter-network of the higher-order functional networks (default mode network, DMN; frontoparietal network, FPN; dorsal attention network, DAN; salience network, SN) were explored in 22 medication-free, community-dwelling, non-help seeking individuals diagnosed with SPD and 30 control individuals. Consequently, while there were no group differences in intra-network functional connectivity across DMN, FPN, DAN, and SN, the SPD participants exhibited attenuated anticorrelation between the right frontal eye field region of the DAN and the right posterior parietal cortex region of the FPN. The decreases in anticorrelation were correlated with increased cognitive–perceptual deficits and disorganization factors of the schizotypal personality questionnaire, as well as reduced independence–performance of the social functioning scale for all participants together. This study, which links SPD pathology and social functioning deficits, is the first evidence of impaired large-scale intrinsic brain networks in SPD.https://www.mdpi.com/2077-0383/10/2/312schizotypal personality disorderresting-state networksresting-state functional connectivity |
| spellingShingle | Ji-Won Hur Taekwan Kim Kang Ik K. Cho Jun Soo Kwon Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder Journal of Clinical Medicine schizotypal personality disorder resting-state networks resting-state functional connectivity |
| title | Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder |
| title_full | Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder |
| title_fullStr | Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder |
| title_full_unstemmed | Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder |
| title_short | Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder |
| title_sort | attenuated resting state functional anticorrelation between attention and executive control networks in schizotypal personality disorder |
| topic | schizotypal personality disorder resting-state networks resting-state functional connectivity |
| url | https://www.mdpi.com/2077-0383/10/2/312 |
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