Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder
Introduction Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823002791/type/journal_article |
| _version_ | 1827753330110103552 |
|---|---|
| author | H. Ferahkaya O. F. Akca I. Kılınç T. Baysal |
| author_facet | H. Ferahkaya O. F. Akca I. Kılınç T. Baysal |
| author_sort | H. Ferahkaya |
| collection | DOAJ |
| description |
Introduction
Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures.
Objectives
This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Methods
A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire and Conner’s Continuous Performance Test. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits.
Results
Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels. (Table 1)
Table 2.
Serum claudin-5, occludin, zonulin and tricellulin levels of ADHD and controls
ADHD(n=57)
Controls(n=60)
Statistical Analysis
ANCOVAc
Mean ± SD
Mean ± SD
z/t
p
F
p
ηp2
Claudin-5 *(ng/mL)
2,14 ± 0,71
2,47 ± 0,71
-3,702
P< 0,001a
10,196
0,002
0,083
Occludin*(ng/mL)
3,75 ± 7,17
2,99 ± 2,75
-0,136
p= 0,892a
0,264
0,608
0,002
Zonulin*(ng/mL)
4,82 ± 5,89
5,06 ± 5,53
-0,076
p= 0,939a
0,008
0,930
< 0,001
Tricellülin(ng/mL)
3,04 ± 0,56
3,34 ± 0,71
-2,552
p= 0.012b
6,650
0,011
0,56
Conclusions
These results suggest that claudin-5 and tricellulin may be involved in the etiopathogenesis of ADHD. Alterations in these peptides may affect the brain by leading a dysregulation in intestinal or blood-brain barrier permeability that eventually affects the gut-brain axis. The causal relationship between these peptides and ADHD requires further investigation.
Disclosure of InterestNone Declared |
| first_indexed | 2024-03-11T07:34:41Z |
| format | Article |
| id | doaj.art-286a8f07bbde492e999cb7bab6131b49 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:34:41Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-286a8f07bbde492e999cb7bab6131b492023-11-17T05:10:24ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S96S9710.1192/j.eurpsy.2023.279Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorderH. Ferahkaya0O. F. Akca1I. Kılınç2T. Baysal3Child and Adolescent Psychiatry, Dr. Ali Kemal Belviranlı Women and Children’s HospitalChild and Adolescent PsychiatryBiochemistryPediatric Cardiology, Necmettin Erbakan University Meram School of Medicine, Konya, Türkiye Introduction Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. Objectives This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents. Methods A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire and Conner’s Continuous Performance Test. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Results Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels. (Table 1) Table 2. Serum claudin-5, occludin, zonulin and tricellulin levels of ADHD and controls ADHD(n=57) Controls(n=60) Statistical Analysis ANCOVAc Mean ± SD Mean ± SD z/t p F p ηp2 Claudin-5 *(ng/mL) 2,14 ± 0,71 2,47 ± 0,71 -3,702 P< 0,001a 10,196 0,002 0,083 Occludin*(ng/mL) 3,75 ± 7,17 2,99 ± 2,75 -0,136 p= 0,892a 0,264 0,608 0,002 Zonulin*(ng/mL) 4,82 ± 5,89 5,06 ± 5,53 -0,076 p= 0,939a 0,008 0,930 < 0,001 Tricellülin(ng/mL) 3,04 ± 0,56 3,34 ± 0,71 -2,552 p= 0.012b 6,650 0,011 0,56 Conclusions These results suggest that claudin-5 and tricellulin may be involved in the etiopathogenesis of ADHD. Alterations in these peptides may affect the brain by leading a dysregulation in intestinal or blood-brain barrier permeability that eventually affects the gut-brain axis. The causal relationship between these peptides and ADHD requires further investigation. Disclosure of InterestNone Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823002791/type/journal_article |
| spellingShingle | H. Ferahkaya O. F. Akca I. Kılınç T. Baysal Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder European Psychiatry |
| title | Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder |
| title_full | Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder |
| title_fullStr | Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder |
| title_full_unstemmed | Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder |
| title_short | Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder |
| title_sort | claudin 5 occludin zonulin and tricellulin levels of children with attention deficit hyperactivity disorder |
| url | https://www.cambridge.org/core/product/identifier/S0924933823002791/type/journal_article |
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