Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

Vaccines are powerful tools to develop immune memory to infectious diseases and prevent excess mortality. In older adults, however vaccines are generally less efficacious and the molecular mechanisms that underpin this remain largely unknown. Autophagy, a process known to prevent aging, is critical...

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Bibliographic Details
Main Authors: Ghada Alsaleh, Isabel Panse, Leo Swadling, Hanlin Zhang, Felix Clemens Richter, Alain Meyer, Janet Lord, Eleanor Barnes, Paul Klenerman, Christopher Green, Anna Katharina Simon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
autophagy
TFEB
human T cells
vaccine
spermidine
Online Access:https://elifesciences.org/articles/57950

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