Repeated Intrastriatal Botulinum Neurotoxin-A Injection in Hemiparkinsonian Rats Increased the Beneficial Effect on Rotational Behavior

Repeated Intrastriatal Botulinum Neurotoxin-A Injection in Hemiparkinsonian Rats Increased the Beneficial Effect on Rotational Behavior

Injection of botulinum neurotoxin-A (BoNT-A) into the striatum of hemiparkinsonian (hemi-PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months. Thereafter, rotation behavior increased again. We injected hemi-PD rats with 1 ng BoNT-A twice, the second injection f...

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Bibliographic Details
Main Authors: Alexander Hawlitschka, Carsten Holzmann, Andreas Wree, Veronica Antipova
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
botulinum neurotoxin-A
striatum
basal ganglia
donepezil
acetylcholine
6-OHDA
Online Access:http://www.mdpi.com/2072-6651/10/9/368

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