Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis

Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis

Abstract The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier dysfunction, inflammation, and dysbiosis. Using the Townes humanized sickle cell mouse model, we found a 3‐fold i...

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Bibliographic Details
Main Authors: Caitlin V. Lewis, Hassan Sellak, Mariem A. Sawan, Giji Joseph, Trevor M. Darby, David VanInsberghe, Crystal R. Naudin, David R. Archer, Rheinallt M. Jones, W. Robert Taylor
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:FASEB BioAdvances
Subjects:
gut microbiome
intestinal permeability
neutrophils
oxidative stress
sickle cell disease
Online Access:https://doi.org/10.1096/fba.2022-00121

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