Epigenetic and Epitranscriptomic Control in Prostate Cancer
The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerg...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/2/378 |
| _version_ | 1797479839778734080 |
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| author | Judith López Ana M. Añazco-Guenkova Óscar Monteagudo-García Sandra Blanco |
| author_facet | Judith López Ana M. Añazco-Guenkova Óscar Monteagudo-García Sandra Blanco |
| author_sort | Judith López |
| collection | DOAJ |
| description | The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer. |
| first_indexed | 2024-03-09T21:51:34Z |
| format | Article |
| id | doaj.art-28704f64237a4372b2122c7c1228bef6 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T21:51:34Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-28704f64237a4372b2122c7c1228bef62023-11-23T20:05:53ZengMDPI AGGenes2073-44252022-02-0113237810.3390/genes13020378Epigenetic and Epitranscriptomic Control in Prostate CancerJudith López0Ana M. Añazco-Guenkova1Óscar Monteagudo-García2Sandra Blanco3Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)—University of Salamanca, 37007 Salamanca, SpainCentro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)—University of Salamanca, 37007 Salamanca, SpainCentro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)—University of Salamanca, 37007 Salamanca, SpainCentro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)—University of Salamanca, 37007 Salamanca, SpainThe initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.https://www.mdpi.com/2073-4425/13/2/378epigeneticsDNA methylationhistone modificationsepitranscriptomicsRNA modificationsprostate cancer |
| spellingShingle | Judith López Ana M. Añazco-Guenkova Óscar Monteagudo-García Sandra Blanco Epigenetic and Epitranscriptomic Control in Prostate Cancer Genes epigenetics DNA methylation histone modifications epitranscriptomics RNA modifications prostate cancer |
| title | Epigenetic and Epitranscriptomic Control in Prostate Cancer |
| title_full | Epigenetic and Epitranscriptomic Control in Prostate Cancer |
| title_fullStr | Epigenetic and Epitranscriptomic Control in Prostate Cancer |
| title_full_unstemmed | Epigenetic and Epitranscriptomic Control in Prostate Cancer |
| title_short | Epigenetic and Epitranscriptomic Control in Prostate Cancer |
| title_sort | epigenetic and epitranscriptomic control in prostate cancer |
| topic | epigenetics DNA methylation histone modifications epitranscriptomics RNA modifications prostate cancer |
| url | https://www.mdpi.com/2073-4425/13/2/378 |
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