Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study
Abstract Background Neuroendocrine tumors (NETs) are rare, which has resulted in a lack of published data on their epidemiology and clinical features. We therefore aimed to investigate the epidemiology, clinical features, treatments, and prognosis of patients with NETs. Methods The clinicopathologic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2259 |
| _version_ | 1828844007975813120 |
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| author | Lijie Song Xuejia Zhai Shunli Yu Yihui Ma Feng Wang Xuxu Yu Shuang Tao Yujin Lian Minjie Yang Weili Tao Qingxia Fan |
| author_facet | Lijie Song Xuejia Zhai Shunli Yu Yihui Ma Feng Wang Xuxu Yu Shuang Tao Yujin Lian Minjie Yang Weili Tao Qingxia Fan |
| author_sort | Lijie Song |
| collection | DOAJ |
| description | Abstract Background Neuroendocrine tumors (NETs) are rare, which has resulted in a lack of published data on their epidemiology and clinical features. We therefore aimed to investigate the epidemiology, clinical features, treatments, and prognosis of patients with NETs. Methods The clinicopathologic characteristics of 547 patients who were pathologically diagnosed with NETs were retrospectively analyzed, including age, sex, primary and metastatic sites, symptoms, pathology, treatment, and prognosis. Results The 547 patients had a wide age range (9‐87 years), with a male to female ratio of 1:1.1. The primary tumor sites included 413 in the digestive system, 74 in the lung, 15 in the mediastinum, 8 in unknown sites, and 37 in other sites. Of the 413 patients with digestive system NETs, the pancreas, rectum, and stomach were the most common primary sites. Blood metastases were found in 84 patients at initial diagnosis, and the liver, bone, and lung were the most frequent sites of metastasis. Lymph node metastases were found in 82 patients at initial diagnosis. Surgery and chemotherapy were the most widely applied treatments. Statistical analysis showed that age <50 years, female sex, lower‐grade tumor, no distant metastasis, intestinal NET and surgery indicated a favorable prognosis. Conclusions A difference between China and other countries is that small intestinal NETs are quite common in other countries but are rare in China. In China, the most common primary sites are the pancreas, rectum, and stomach. Furthermore, no unified treatments exist, though prognoses could be improved by using methods such as surgery, targeted therapies, and somatostatin analogs. Clinical Trial Registration This study was not a clinical trial. |
| first_indexed | 2024-12-12T20:57:42Z |
| format | Article |
| id | doaj.art-28784249a2ae4683b8c86e896f25e445 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-12T20:57:42Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-28784249a2ae4683b8c86e896f25e4452022-12-22T00:12:15ZengWileyCancer Medicine2045-76342019-07-01883729373710.1002/cam4.2259Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center studyLijie Song0Xuejia Zhai1Shunli Yu2Yihui Ma3Feng Wang4Xuxu Yu5Shuang Tao6Yujin Lian7Minjie Yang8Weili Tao9Qingxia Fan10Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaAbstract Background Neuroendocrine tumors (NETs) are rare, which has resulted in a lack of published data on their epidemiology and clinical features. We therefore aimed to investigate the epidemiology, clinical features, treatments, and prognosis of patients with NETs. Methods The clinicopathologic characteristics of 547 patients who were pathologically diagnosed with NETs were retrospectively analyzed, including age, sex, primary and metastatic sites, symptoms, pathology, treatment, and prognosis. Results The 547 patients had a wide age range (9‐87 years), with a male to female ratio of 1:1.1. The primary tumor sites included 413 in the digestive system, 74 in the lung, 15 in the mediastinum, 8 in unknown sites, and 37 in other sites. Of the 413 patients with digestive system NETs, the pancreas, rectum, and stomach were the most common primary sites. Blood metastases were found in 84 patients at initial diagnosis, and the liver, bone, and lung were the most frequent sites of metastasis. Lymph node metastases were found in 82 patients at initial diagnosis. Surgery and chemotherapy were the most widely applied treatments. Statistical analysis showed that age <50 years, female sex, lower‐grade tumor, no distant metastasis, intestinal NET and surgery indicated a favorable prognosis. Conclusions A difference between China and other countries is that small intestinal NETs are quite common in other countries but are rare in China. In China, the most common primary sites are the pancreas, rectum, and stomach. Furthermore, no unified treatments exist, though prognoses could be improved by using methods such as surgery, targeted therapies, and somatostatin analogs. Clinical Trial Registration This study was not a clinical trial.https://doi.org/10.1002/cam4.2259epidemiologyneuroendocrine tumorspathologyprognosistreatments |
| spellingShingle | Lijie Song Xuejia Zhai Shunli Yu Yihui Ma Feng Wang Xuxu Yu Shuang Tao Yujin Lian Minjie Yang Weili Tao Qingxia Fan Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study Cancer Medicine epidemiology neuroendocrine tumors pathology prognosis treatments |
| title | Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study |
| title_full | Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study |
| title_fullStr | Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study |
| title_full_unstemmed | Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study |
| title_short | Clinical analysis of 547 patients with neuroendocrine tumors in a Chinese population: A single‐center study |
| title_sort | clinical analysis of 547 patients with neuroendocrine tumors in a chinese population a single center study |
| topic | epidemiology neuroendocrine tumors pathology prognosis treatments |
| url | https://doi.org/10.1002/cam4.2259 |
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