Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study
Abstract Background Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. Several studies have reported adverse health effects with BPA exposures, namely metabolic disorders and altered neurodevelopment in children, among others. The aim of...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-021-00777-0 |
| _version_ | 1827982889330933760 |
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| author | Mercè Garí Rebecca Moos Daniel Bury Monika Kasper-Sonnenberg Agnieszka Jankowska Aleksandra Andysz Wojciech Hanke Dennis Nowak Stephan Bose-O’Reilly Holger M. Koch Kinga Polanska |
| author_facet | Mercè Garí Rebecca Moos Daniel Bury Monika Kasper-Sonnenberg Agnieszka Jankowska Aleksandra Andysz Wojciech Hanke Dennis Nowak Stephan Bose-O’Reilly Holger M. Koch Kinga Polanska |
| author_sort | Mercè Garí |
| collection | DOAJ |
| description | Abstract Background Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. Several studies have reported adverse health effects with BPA exposures, namely metabolic disorders and altered neurodevelopment in children, among others. The aim of this study was to explore BPA exposure, its socio-demographic and life-style related determinants, and its association with neurodevelopmental outcomes in early school age children from Poland. Methods A total of 250 urine samples of 7 year-old children from the Polish Mother and Child Cohort Study (REPRO_PL) were analyzed for BPA concentrations using high performance liquid chromatography with online sample clean-up coupled to tandem mass spectrometry (online-SPE-LC-MS/MS). Socio-demographic and lifestyle-related data was collected by questionnaires or additional biomarker measurements. Emotional and behavioral symptoms in children were assessed using mother-reported Strengths and Difficulties Questionnaire (SDQ). Cognitive and psychomotor development was evaluated by Polish adaptation of the Intelligence and Development Scales (IDS) performed by trained psychologists. Results Urinary BPA concentrations and back-calculated daily intakes (medians of 1.8 μg/l and 46.3 ng/kg bw/day, respectively) were similar to other European studies. Urinary cotinine levels and body mass index, together with maternal educational level and socio-economic status, were the main determinants of BPA levels in Polish children. After adjusting for confounding factors, BPA has been found to be positively associated with emotional symptoms (β: 0.14, 95% CI: 0.022; 0.27). Cognitive and psychomotor development were not found to be related to BPA levels. Conclusions This study represents the first report of BPA levels and their determinants in school age children in Poland. The exposure level was found to be related to child emotional condition, which can have long-term consequences including social functioning and scholastic achievements. Further monitoring of this population in terms of overall chemical exposure is required. |
| first_indexed | 2024-04-09T22:39:03Z |
| format | Article |
| id | doaj.art-287a705106fe440b81f8911409e8cceb |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-09T22:39:03Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-287a705106fe440b81f8911409e8cceb2023-03-22T12:16:20ZengBMCEnvironmental Health1476-069X2021-08-0120111410.1186/s12940-021-00777-0Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort StudyMercè Garí0Rebecca Moos1Daniel Bury2Monika Kasper-Sonnenberg3Agnieszka Jankowska4Aleksandra Andysz5Wojciech Hanke6Dennis Nowak7Stephan Bose-O’Reilly8Holger M. Koch9Kinga Polanska10Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich. Institute of Computational BiologyInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine (NIOM)Department of Health and Work Psychology, Nofer Institute of Occupational Medicine (NIOM)Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine (NIOM)Institute and Clinic for Occupational, Social and Environmental Medicine, University HospitalInstitute and Clinic for Occupational, Social and Environmental Medicine, University HospitalInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA)Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine (NIOM)Abstract Background Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. Several studies have reported adverse health effects with BPA exposures, namely metabolic disorders and altered neurodevelopment in children, among others. The aim of this study was to explore BPA exposure, its socio-demographic and life-style related determinants, and its association with neurodevelopmental outcomes in early school age children from Poland. Methods A total of 250 urine samples of 7 year-old children from the Polish Mother and Child Cohort Study (REPRO_PL) were analyzed for BPA concentrations using high performance liquid chromatography with online sample clean-up coupled to tandem mass spectrometry (online-SPE-LC-MS/MS). Socio-demographic and lifestyle-related data was collected by questionnaires or additional biomarker measurements. Emotional and behavioral symptoms in children were assessed using mother-reported Strengths and Difficulties Questionnaire (SDQ). Cognitive and psychomotor development was evaluated by Polish adaptation of the Intelligence and Development Scales (IDS) performed by trained psychologists. Results Urinary BPA concentrations and back-calculated daily intakes (medians of 1.8 μg/l and 46.3 ng/kg bw/day, respectively) were similar to other European studies. Urinary cotinine levels and body mass index, together with maternal educational level and socio-economic status, were the main determinants of BPA levels in Polish children. After adjusting for confounding factors, BPA has been found to be positively associated with emotional symptoms (β: 0.14, 95% CI: 0.022; 0.27). Cognitive and psychomotor development were not found to be related to BPA levels. Conclusions This study represents the first report of BPA levels and their determinants in school age children in Poland. The exposure level was found to be related to child emotional condition, which can have long-term consequences including social functioning and scholastic achievements. Further monitoring of this population in terms of overall chemical exposure is required.https://doi.org/10.1186/s12940-021-00777-0Birth cohortBisphenol AChildrenDaily IntakeNeurodevelopmentPoland |
| spellingShingle | Mercè Garí Rebecca Moos Daniel Bury Monika Kasper-Sonnenberg Agnieszka Jankowska Aleksandra Andysz Wojciech Hanke Dennis Nowak Stephan Bose-O’Reilly Holger M. Koch Kinga Polanska Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study Environmental Health Birth cohort Bisphenol A Children Daily Intake Neurodevelopment Poland |
| title | Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study |
| title_full | Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study |
| title_fullStr | Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study |
| title_full_unstemmed | Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study |
| title_short | Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study |
| title_sort | human biomonitoring derived exposure and daily intakes of bisphenol a and their associations with neurodevelopmental outcomes among children of the polish mother and child cohort study |
| topic | Birth cohort Bisphenol A Children Daily Intake Neurodevelopment Poland |
| url | https://doi.org/10.1186/s12940-021-00777-0 |
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