Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study
When mood states are impaired, daily life is severely disrupted. To maintain a specific mood state, both positive and negative moods must be controlled; however, methods to maintain a positive mood have not been fully established. Previous studies have suggested that heat-killed <i>L. helvetic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/6/973 |
| _version_ | 1797595661053460480 |
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| author | Natsumi Mutoh Izumi Kakiuchi Kumiko Kato Chendong Xu Noriyuki Iwabuchi Masayo Ayukawa Kyoko Kiyosawa Kazumi Igarashi Miyuki Tanaka Masahiko Nakamura Mitsunaga Miyasaka |
| author_facet | Natsumi Mutoh Izumi Kakiuchi Kumiko Kato Chendong Xu Noriyuki Iwabuchi Masayo Ayukawa Kyoko Kiyosawa Kazumi Igarashi Miyuki Tanaka Masahiko Nakamura Mitsunaga Miyasaka |
| author_sort | Natsumi Mutoh |
| collection | DOAJ |
| description | When mood states are impaired, daily life is severely disrupted. To maintain a specific mood state, both positive and negative moods must be controlled; however, methods to maintain a positive mood have not been fully established. Previous studies have suggested that heat-killed <i>L. helveticus</i> MCC1848 has the potential to improve positive moods. This study aimed to test the efficacy of heat-killed <i>L. helveticus</i> MCC1848 in maintaining and improving a positive mood with PANAS, a questionnaire specifically designed to assess positive and negative mood, as the primary endpoint. Healthy Japanese nursing students (<i>n</i> = 46) were randomized to receive heat-killed <i>L. helveticus</i> MCC1848 (5 billion/day) or placebo powder for four weeks. Mood state was assessed before and two and four weeks after the intervention began; ingestion of heat-killed <i>L. helveticus</i> MCC1848 significantly improved PANAS ‘Positive Affect’ compared to the placebo. These results indicate that heat-killed <i>L. helveticus</i> MCC1848 is effective in enhancing positive mood. |
| first_indexed | 2024-03-11T02:40:30Z |
| format | Article |
| id | doaj.art-287b451ec4dc4598af2800e733dd6d31 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T02:40:30Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-287b451ec4dc4598af2800e733dd6d312023-11-18T09:37:09ZengMDPI AGBrain Sciences2076-34252023-06-0113697310.3390/brainsci13060973Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled StudyNatsumi Mutoh0Izumi Kakiuchi1Kumiko Kato2Chendong Xu3Noriyuki Iwabuchi4Masayo Ayukawa5Kyoko Kiyosawa6Kazumi Igarashi7Miyuki Tanaka8Masahiko Nakamura9Mitsunaga Miyasaka10Innovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-City 252-8583, Kanagawa, JapanFaculty of Nursing, Matsumoto College of Nursing, 3118, Sasaga, Matsumoto-City 399-0033, Nagano, JapanInnovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-City 252-8583, Kanagawa, JapanInnovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-City 252-8583, Kanagawa, JapanInnovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-City 252-8583, Kanagawa, JapanFaculty of Nursing, Matsumoto College of Nursing, 3118, Sasaga, Matsumoto-City 399-0033, Nagano, JapanDepartment of Nursing, Matsumoto Junior College, 3118, Sasaga, Matsumoto-City 399-0033, Nagano, JapanFaculty of Nursing, Matsumoto College of Nursing, 3118, Sasaga, Matsumoto-City 399-0033, Nagano, JapanInnovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-City 252-8583, Kanagawa, JapanMatsumoto City Hospital, 4417-180 Hata, Matsumoto-City 390-1401, Nagano, JapanFaculty of Nursing, Matsumoto College of Nursing, 3118, Sasaga, Matsumoto-City 399-0033, Nagano, JapanWhen mood states are impaired, daily life is severely disrupted. To maintain a specific mood state, both positive and negative moods must be controlled; however, methods to maintain a positive mood have not been fully established. Previous studies have suggested that heat-killed <i>L. helveticus</i> MCC1848 has the potential to improve positive moods. This study aimed to test the efficacy of heat-killed <i>L. helveticus</i> MCC1848 in maintaining and improving a positive mood with PANAS, a questionnaire specifically designed to assess positive and negative mood, as the primary endpoint. Healthy Japanese nursing students (<i>n</i> = 46) were randomized to receive heat-killed <i>L. helveticus</i> MCC1848 (5 billion/day) or placebo powder for four weeks. Mood state was assessed before and two and four weeks after the intervention began; ingestion of heat-killed <i>L. helveticus</i> MCC1848 significantly improved PANAS ‘Positive Affect’ compared to the placebo. These results indicate that heat-killed <i>L. helveticus</i> MCC1848 is effective in enhancing positive mood.https://www.mdpi.com/2076-3425/13/6/973gut-brain axispsychobioticspositive moodparaprobiotics |
| spellingShingle | Natsumi Mutoh Izumi Kakiuchi Kumiko Kato Chendong Xu Noriyuki Iwabuchi Masayo Ayukawa Kyoko Kiyosawa Kazumi Igarashi Miyuki Tanaka Masahiko Nakamura Mitsunaga Miyasaka Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study Brain Sciences gut-brain axis psychobiotics positive mood paraprobiotics |
| title | Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full | Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_fullStr | Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full_unstemmed | Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_short | Heat-Killed <i>L. helveticus</i> Enhances Positive Mood States: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_sort | heat killed i l helveticus i enhances positive mood states a randomized double blind placebo controlled study |
| topic | gut-brain axis psychobiotics positive mood paraprobiotics |
| url | https://www.mdpi.com/2076-3425/13/6/973 |
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