Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling

Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling

A subset of long non-coding RNAs (lncRNAs), categorized as miRNA-host gene lncRNAs (lnc-miRHGs), is processed to produce miRNAs and involved in cancer progression. This work aimed to investigate the influences and the molecular mechanisms of lnc-miRHGs MIR497HG in bladder cancer (BCa). The miR-497 a...

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Bibliographic Details
Main Authors: Changshui Zhuang, Ying Liu, Shengqiang Fu, Chaobo Yuan, Jingwen Luo, Xueting Huang, Weifeng Yang, Wuwei Xie, Chengle Zhuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
bladder cancer
MIR497HG
CRISPR/Cas13d
Yap
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.616768/full

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