Expression of p53 Protein Associates with Anti-PD-L1 Treatment Response on Human-Derived Xenograft Model of GATA3/CR5/6-Negative Recurrent Nonmuscular Invasive Bladder Urothelial Carcinoma

Expression of p53 Protein Associates with Anti-PD-L1 Treatment Response on Human-Derived Xenograft Model of GATA3/CR5/6-Negative Recurrent Nonmuscular Invasive Bladder Urothelial Carcinoma

Background: The possible involvement of p53 signaling, FGFR3 expression, and <i>FGFR3</i> mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3 expression, and...

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Main Authors: Ekaterina Blinova, Elena Samishina, Olga Deryabina, Dmitry Blinov, Dmitry Roshchin, Evgeniia Shich, Oxana Tumutolova, Ilya Fedoseykin, Anna Epishkina, Haydar Barakat, Andrey Kaprin, Kirill Zhandarov, Dmitrij Perepechin, Dmitrij Merinov, Gordey Brykin, Karen Arutiunian, Stanislav Serebrianyi, Artem Mirontsev, Andrew Kozdoba
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
nonmuscular invasive bladder cancer
p53 expression
double-negative molecular subtype
<i>FGFR3</i> mutations
FGFR3 expression
anti-PD-L1 therapy
Online Access:https://www.mdpi.com/1422-0067/22/18/9856

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https://www.mdpi.com/1422-0067/22/18/9856

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