Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus
Pregnancy is a special physiological condition, where drug treatment presents a special concern. The use of drugs during pregnancy is increasing. Micronuclei, chromosomal aberrations, and sister chromatid exchanges are biomarkers of early biological effects which play an important role in assessing...
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| Format: | Article |
| Language: | English |
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University of Kragujevac, Faculty of Science
2023-01-01
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| Series: | Kragujevac Journal of Science |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345129Q.pdf |
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| author | Đorđević Katarina M. Arsenijević Slobodan N. Milošević-Đorđević Olivera M. Marinković Dragoslav M. Grujičić Darko V. |
| author_facet | Đorđević Katarina M. Arsenijević Slobodan N. Milošević-Đorđević Olivera M. Marinković Dragoslav M. Grujičić Darko V. |
| author_sort | Đorđević Katarina M. |
| collection | DOAJ |
| description | Pregnancy is a special physiological condition, where drug treatment presents a special concern. The use of drugs during pregnancy is increasing. Micronuclei, chromosomal aberrations, and sister chromatid exchanges are biomarkers of early biological effects which play an important role in assessing the genetic integrity of both individuals and populations. The aim of this review is to make a cross-section of previously conducted studies on the detections of genotoxic effects of drugs on human peripheral blood lymphocytes, after therapeutic exposure during the second and third trimester of pregnancy, as well as in umbilical blood lymphocytes of newborns whose mothers received the same therapy. Previous studies have shown that the cells of pregnant women and newborns are very sensitive to the effects of genotoxins, and cytogenetic biomarkers are associated with the risk of developing numerous diseases, including cancer in adults. Altogether, the administration of various doses and times of use of medications should be performed with caution. |
| first_indexed | 2024-03-12T14:59:15Z |
| format | Article |
| id | doaj.art-287f06c4205646c18943f4dff5a8b0ca |
| institution | Directory Open Access Journal |
| issn | 1450-9636 2466-5509 |
| language | English |
| last_indexed | 2024-03-12T14:59:15Z |
| publishDate | 2023-01-01 |
| publisher | University of Kragujevac, Faculty of Science |
| record_format | Article |
| series | Kragujevac Journal of Science |
| spelling | doaj.art-287f06c4205646c18943f4dff5a8b0ca2023-08-14T09:28:40ZengUniversity of Kragujevac, Faculty of ScienceKragujevac Journal of Science1450-96362466-55092023-01-012023451291471450-96362345129QPharmacotherapy during pregnancy and its association with genome instability in mother and fetusĐorđević Katarina M.0Arsenijević Slobodan N.1https://orcid.org/0000-0003-0494-1492Milošević-Đorđević Olivera M.2https://orcid.org/0000-0002-4973-1301Marinković Dragoslav M.3Grujičić Darko V.4https://orcid.org/0000-0001-7955-6076University of , Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Gynecology and Obstetrics, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, SerbiaSerbian Academy of Sciences and Arts, Belgrade, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, SerbiaPregnancy is a special physiological condition, where drug treatment presents a special concern. The use of drugs during pregnancy is increasing. Micronuclei, chromosomal aberrations, and sister chromatid exchanges are biomarkers of early biological effects which play an important role in assessing the genetic integrity of both individuals and populations. The aim of this review is to make a cross-section of previously conducted studies on the detections of genotoxic effects of drugs on human peripheral blood lymphocytes, after therapeutic exposure during the second and third trimester of pregnancy, as well as in umbilical blood lymphocytes of newborns whose mothers received the same therapy. Previous studies have shown that the cells of pregnant women and newborns are very sensitive to the effects of genotoxins, and cytogenetic biomarkers are associated with the risk of developing numerous diseases, including cancer in adults. Altogether, the administration of various doses and times of use of medications should be performed with caution.https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345129Q.pdfpregnancypharmacotherapygenome instabilityhuman peripheral blood lymphocytesumbilical blood lymphocytes |
| spellingShingle | Đorđević Katarina M. Arsenijević Slobodan N. Milošević-Đorđević Olivera M. Marinković Dragoslav M. Grujičić Darko V. Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus Kragujevac Journal of Science pregnancy pharmacotherapy genome instability human peripheral blood lymphocytes umbilical blood lymphocytes |
| title | Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| title_full | Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| title_fullStr | Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| title_full_unstemmed | Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| title_short | Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| title_sort | pharmacotherapy during pregnancy and its association with genome instability in mother and fetus |
| topic | pregnancy pharmacotherapy genome instability human peripheral blood lymphocytes umbilical blood lymphocytes |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345129Q.pdf |
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