Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations
<strong>Abstract</strong><br /> A simple, accurate, rapid and sensitive visible spectrophotometric method has been developed for the determination of tolnaftate in pure and pharmaceutical preparations. The method is based on the reaction of tolnaftate with potassium permanganate in...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
1970-01-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_161563_f801bd5a845603984b68399b3f62ec81.pdf |
| _version_ | 1828409341391142912 |
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| author | Nief Ahmed Nawfal Mohamad |
| author_facet | Nief Ahmed Nawfal Mohamad |
| author_sort | Nief Ahmed |
| collection | DOAJ |
| description | <strong>Abstract</strong><br /> A simple, accurate, rapid and sensitive visible spectrophotometric method has been developed for the determination of tolnaftate in pure and pharmaceutical preparations. The method is based on the reaction of tolnaftate with potassium permanganate in alkaline medium to form a bluish green colored product with an absorption maximum at 610 nm. Beer’s law was obeyed in the range of 5-60 µg/25ml with a molar absorbitivity of 5.379×10<sup>4 </sup>L.mol.<sup>-1</sup>.cm<sup>-1</sup>. The optimum conditions for all color development were described and the proposed method has been successfully applied for the determination of tolnaftate in pharmaceutical preparations. A statistical comparison of these results with those of official method using (t and F) values at 95% confidence level, The calculated t- and F- values did not exceed the theoretical values indicating that there was no significant differences between the precision of the proposed and official method. So that the proposed method can be used as a routine quality control for determination of tolnaftate in pure form and in pharmaceutical formulations.The common excipients and additives did not interfere in the proposed method. |
| first_indexed | 2024-12-10T11:54:26Z |
| format | Article |
| id | doaj.art-287f3a48a4404e0d9e5997f3baf412c0 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-10T11:54:26Z |
| publishDate | 1970-01-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-287f3a48a4404e0d9e5997f3baf412c02022-12-22T01:49:50ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25301970-01-01271354210.33899/edusj.1970.161563161563Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparationsNief Ahmed0Nawfal Mohamad1Department of Environmental Technology, College of Environment, University of Mosul, Mosul, IraqDepartment of Chemistry, College of Education, University of Mosul, Mosul, Iraq<strong>Abstract</strong><br /> A simple, accurate, rapid and sensitive visible spectrophotometric method has been developed for the determination of tolnaftate in pure and pharmaceutical preparations. The method is based on the reaction of tolnaftate with potassium permanganate in alkaline medium to form a bluish green colored product with an absorption maximum at 610 nm. Beer’s law was obeyed in the range of 5-60 µg/25ml with a molar absorbitivity of 5.379×10<sup>4 </sup>L.mol.<sup>-1</sup>.cm<sup>-1</sup>. The optimum conditions for all color development were described and the proposed method has been successfully applied for the determination of tolnaftate in pharmaceutical preparations. A statistical comparison of these results with those of official method using (t and F) values at 95% confidence level, The calculated t- and F- values did not exceed the theoretical values indicating that there was no significant differences between the precision of the proposed and official method. So that the proposed method can be used as a routine quality control for determination of tolnaftate in pure form and in pharmaceutical formulations.The common excipients and additives did not interfere in the proposed method.https://edusj.mosuljournals.com/article_161563_f801bd5a845603984b68399b3f62ec81.pdftolnaftatepotassium permangnatespectrophotometric |
| spellingShingle | Nief Ahmed Nawfal Mohamad Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations مجلة التربية والعلم tolnaftate potassium permangnate spectrophotometric |
| title | Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| title_full | Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| title_fullStr | Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| title_full_unstemmed | Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| title_short | Spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| title_sort | spectrophotometric method for the determination of tolnaftate in pharmaceutical preparations |
| topic | tolnaftate potassium permangnate spectrophotometric |
| url | https://edusj.mosuljournals.com/article_161563_f801bd5a845603984b68399b3f62ec81.pdf |
| work_keys_str_mv | AT niefahmed spectrophotometricmethodforthedeterminationoftolnaftateinpharmaceuticalpreparations AT nawfalmohamad spectrophotometricmethodforthedeterminationoftolnaftateinpharmaceuticalpreparations |