<i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain
The management of orofacial pain to alleviate the quality of life of affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition to conventional therapies, new alternatives are being sought, increasingly looking at t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/1/106 |
| _version_ | 1797406695287160832 |
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| author | Giuseppina Crescente Giuseppe Minervini Carmela Spagnuolo Stefania Moccia |
| author_facet | Giuseppina Crescente Giuseppe Minervini Carmela Spagnuolo Stefania Moccia |
| author_sort | Giuseppina Crescente |
| collection | DOAJ |
| description | The management of orofacial pain to alleviate the quality of life of affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition to conventional therapies, new alternatives are being sought, increasingly looking at the use of both natural and synthetic products. <i>Cannabis sativa</i> L. represents an interesting source of bioactive compounds, including non-psychoactive cannabinoids, flavonoids, and terpenes, many of which are effective in improving pain intensity. Here, we aim to analyze the possible mechanisms of action of the bioactive natural and synthetic hemp-derived compounds responsible for the modulatory effects on pain-related pathways. The ability of these compounds to act on multiple mechanisms through a synergistic effect, reducing both the release of inflammatory mediators and regulating the response of the endocannabinoid system, makes them interesting agents for alternative formulations to be used in orofacial pain. |
| first_indexed | 2024-03-09T03:30:16Z |
| format | Article |
| id | doaj.art-287f3c486e564f1d9e4a5159830c8726 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T03:30:16Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-287f3c486e564f1d9e4a5159830c87262023-12-03T14:56:39ZengMDPI AGMolecules1420-30492022-12-0128110610.3390/molecules28010106<i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial PainGiuseppina Crescente0Giuseppe Minervini1Carmela Spagnuolo2Stefania Moccia3National Research Council, Institute of Food Sciences, 83100 Avellino, ItalyMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania, Luigi Vanvitelli, 80138 Naples, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyThe management of orofacial pain to alleviate the quality of life of affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition to conventional therapies, new alternatives are being sought, increasingly looking at the use of both natural and synthetic products. <i>Cannabis sativa</i> L. represents an interesting source of bioactive compounds, including non-psychoactive cannabinoids, flavonoids, and terpenes, many of which are effective in improving pain intensity. Here, we aim to analyze the possible mechanisms of action of the bioactive natural and synthetic hemp-derived compounds responsible for the modulatory effects on pain-related pathways. The ability of these compounds to act on multiple mechanisms through a synergistic effect, reducing both the release of inflammatory mediators and regulating the response of the endocannabinoid system, makes them interesting agents for alternative formulations to be used in orofacial pain.https://www.mdpi.com/1420-3049/28/1/106<i>Cannabis sativa</i> L.cannabinoidsterpenesorofacial paintemporomandibular disordersinflammation |
| spellingShingle | Giuseppina Crescente Giuseppe Minervini Carmela Spagnuolo Stefania Moccia <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain Molecules <i>Cannabis sativa</i> L. cannabinoids terpenes orofacial pain temporomandibular disorders inflammation |
| title | <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain |
| title_full | <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain |
| title_fullStr | <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain |
| title_full_unstemmed | <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain |
| title_short | <i>Cannabis</i> Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain |
| title_sort | i cannabis i bioactive compound based formulations new perspectives for the management of orofacial pain |
| topic | <i>Cannabis sativa</i> L. cannabinoids terpenes orofacial pain temporomandibular disorders inflammation |
| url | https://www.mdpi.com/1420-3049/28/1/106 |
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