Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension
Background Right heart failure may lead to impaired liver perfusion and venous congestion, resulting in different extents of liver fibrosis. However, whether hepatic tissue deterioration determined by native T1 mapping and extracellular volume fraction using cardiac magnetic resonance imaging is ass...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.026254 |
| _version_ | 1811170022524977152 |
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| author | Jiajun Guo Lili Wang Jiaqi Wang Ke Wan Chao Gong Xiaoling Chen Jinghua Guo Yuanwei Xu Juan He Lidan Yin Shoufang Pu Bi Wen Chen Chen Yuchi Han Yucheng Chen |
| author_facet | Jiajun Guo Lili Wang Jiaqi Wang Ke Wan Chao Gong Xiaoling Chen Jinghua Guo Yuanwei Xu Juan He Lidan Yin Shoufang Pu Bi Wen Chen Chen Yuchi Han Yucheng Chen |
| author_sort | Jiajun Guo |
| collection | DOAJ |
| description | Background Right heart failure may lead to impaired liver perfusion and venous congestion, resulting in different extents of liver fibrosis. However, whether hepatic tissue deterioration determined by native T1 mapping and extracellular volume fraction using cardiac magnetic resonance imaging is associated with poor outcomes in patients with pulmonary arterial hypertension remains unclear. Methods and Results A total of 131 participants with pulmonary arterial hypertension (mean age, 36±13 years) and 64 healthy controls (mean age, 44±18) between October 2013 and December 2019 were prospectively enrolled. Hepatic native T1 and extracellular volume fraction values were measured using modified Look–Locker inversion recovery T1 mapping sequences. The primary end point was all‐cause mortality; the secondary end point was all‐cause mortality and repeat hospitalization attributable to heart failure. Cox regression models and Kaplan–Meier survival analysis were used to identify the association between variables and clinical outcome. During a median follow‐up of 34.5 months (interquartile range: 25.3–50.8), hepatic native T1 (hazard ratio per 30‐ms increase, 1.22 [95% CI, 1.07–1.39]; P=0.003) and extracellular volume fraction (hazard ratio per 3% increase, 1.18 [95% CI, 1.04–1.34]; P=0.010) values were associated with a higher risk of death. In the multivariate Cox model, hepatic native T1 value (hazard ratio per 30‐ms increase, 1.15 [95% CI, 1.04–1.27]; P=0.009) remained as an independent prognostic factor for the secondary end point. Conclusions Hepatic T1 mapping values were predictors of adverse cardiovascular events in participants with pulmonary arterial hypertension and could be novel imaging biomarkers for poor prognosis recognition. |
| first_indexed | 2024-04-10T16:51:42Z |
| format | Article |
| id | doaj.art-288290bbaa0643aab12bc1cc08a3d6ed |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T16:51:42Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-288290bbaa0643aab12bc1cc08a3d6ed2023-02-07T16:02:48ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-11-01112210.1161/JAHA.122.026254Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial HypertensionJiajun Guo0Lili Wang1Jiaqi Wang2Ke Wan3Chao Gong4Xiaoling Chen5Jinghua Guo6Yuanwei Xu7Juan He8Lidan Yin9Shoufang Pu10Bi Wen11Chen Chen12Yuchi Han13Yucheng Chen14Department of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Geriatrics, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaCardiovascular Medicine, Wexner Medical Center, College of Medicine The Ohio State University Columbus OhioDepartment of Cardiology, West China Hospital Sichuan University Chengdu ChinaBackground Right heart failure may lead to impaired liver perfusion and venous congestion, resulting in different extents of liver fibrosis. However, whether hepatic tissue deterioration determined by native T1 mapping and extracellular volume fraction using cardiac magnetic resonance imaging is associated with poor outcomes in patients with pulmonary arterial hypertension remains unclear. Methods and Results A total of 131 participants with pulmonary arterial hypertension (mean age, 36±13 years) and 64 healthy controls (mean age, 44±18) between October 2013 and December 2019 were prospectively enrolled. Hepatic native T1 and extracellular volume fraction values were measured using modified Look–Locker inversion recovery T1 mapping sequences. The primary end point was all‐cause mortality; the secondary end point was all‐cause mortality and repeat hospitalization attributable to heart failure. Cox regression models and Kaplan–Meier survival analysis were used to identify the association between variables and clinical outcome. During a median follow‐up of 34.5 months (interquartile range: 25.3–50.8), hepatic native T1 (hazard ratio per 30‐ms increase, 1.22 [95% CI, 1.07–1.39]; P=0.003) and extracellular volume fraction (hazard ratio per 3% increase, 1.18 [95% CI, 1.04–1.34]; P=0.010) values were associated with a higher risk of death. In the multivariate Cox model, hepatic native T1 value (hazard ratio per 30‐ms increase, 1.15 [95% CI, 1.04–1.27]; P=0.009) remained as an independent prognostic factor for the secondary end point. Conclusions Hepatic T1 mapping values were predictors of adverse cardiovascular events in participants with pulmonary arterial hypertension and could be novel imaging biomarkers for poor prognosis recognition.https://www.ahajournals.org/doi/10.1161/JAHA.122.026254cardiovascular magnetic resonancehepatic T1 mappingprognosispulmonary arterial hypertension |
| spellingShingle | Jiajun Guo Lili Wang Jiaqi Wang Ke Wan Chao Gong Xiaoling Chen Jinghua Guo Yuanwei Xu Juan He Lidan Yin Shoufang Pu Bi Wen Chen Chen Yuchi Han Yucheng Chen Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular magnetic resonance hepatic T1 mapping prognosis pulmonary arterial hypertension |
| title | Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension |
| title_full | Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension |
| title_fullStr | Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension |
| title_full_unstemmed | Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension |
| title_short | Prognostic Value of Hepatic Native T1 and Extracellular Volume Fraction in Patients with Pulmonary Arterial Hypertension |
| title_sort | prognostic value of hepatic native t1 and extracellular volume fraction in patients with pulmonary arterial hypertension |
| topic | cardiovascular magnetic resonance hepatic T1 mapping prognosis pulmonary arterial hypertension |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.026254 |
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