Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties
Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/10/970 |
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| author | Gonçalo Garcia Teresa Faria Pais Paula Pinto Gary Dobson Gordon J. McDougall Derek Stewart Cláudia Nunes Santos |
| author_facet | Gonçalo Garcia Teresa Faria Pais Paula Pinto Gary Dobson Gordon J. McDougall Derek Stewart Cláudia Nunes Santos |
| author_sort | Gonçalo Garcia |
| collection | DOAJ |
| description | Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-α, and intracellular superoxide via NF-κB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammation |
| first_indexed | 2024-03-10T15:44:08Z |
| format | Article |
| id | doaj.art-2882d72acfd0421fb7637537efdbf9c0 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T15:44:08Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2882d72acfd0421fb7637537efdbf9c02023-11-20T16:31:20ZengMDPI AGAntioxidants2076-39212020-10-0191097010.3390/antiox9100970Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory PropertiesGonçalo Garcia0Teresa Faria Pais1Paula Pinto2Gary Dobson3Gordon J. McDougall4Derek Stewart5Cláudia Nunes Santos6Instituto de Biologia Experimental e Tecnológica (iBET), apartado 12, 2781-901 Oeiras, PortugalInstituto de Biologia Experimental e Tecnológica (iBET), apartado 12, 2781-901 Oeiras, PortugalITQB, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, PortugalPlant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UKPlant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UKPlant Biochemistry and Food Quality Group, Environmental and Biochemical Science, The James Hutton Institute, Dundee DD2 5DA, Scotland, UKInstituto de Biologia Experimental e Tecnológica (iBET), apartado 12, 2781-901 Oeiras, PortugalChronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-α, and intracellular superoxide via NF-κB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammationhttps://www.mdpi.com/2076-3921/9/10/970polyphenol metabolitesgastro-intestinal digestionneuroinflammationmicrogliaNF-kappaB |
| spellingShingle | Gonçalo Garcia Teresa Faria Pais Paula Pinto Gary Dobson Gordon J. McDougall Derek Stewart Cláudia Nunes Santos Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties Antioxidants polyphenol metabolites gastro-intestinal digestion neuroinflammation microglia NF-kappaB |
| title | Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties |
| title_full | Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties |
| title_fullStr | Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties |
| title_full_unstemmed | Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties |
| title_short | Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties |
| title_sort | bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti neuroinflammatory properties |
| topic | polyphenol metabolites gastro-intestinal digestion neuroinflammation microglia NF-kappaB |
| url | https://www.mdpi.com/2076-3921/9/10/970 |
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