The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study
Abstract Background Dental caries is one of the most prevalent chronic diseases worldwide among children. The rs35874116 single nucleotide polymorphism (SNP) in the sweet receptor gene TAS1R2 has been associated with dental caries at a high risk in permanent teeth among school children and adults. T...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-022-02512-8 |
| _version_ | 1811329016018239488 |
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| author | Yan Liang Junyu Yao Rongmin Qiu Aihua Chen Hua Huang Huancai Lin Lixia Yu |
| author_facet | Yan Liang Junyu Yao Rongmin Qiu Aihua Chen Hua Huang Huancai Lin Lixia Yu |
| author_sort | Yan Liang |
| collection | DOAJ |
| description | Abstract Background Dental caries is one of the most prevalent chronic diseases worldwide among children. The rs35874116 single nucleotide polymorphism (SNP) in the sweet receptor gene TAS1R2 has been associated with dental caries at a high risk in permanent teeth among school children and adults. To date, little is known about the association of this SNP with sweet intake and caries risk in the primary school children. Methods Total of 236 children were included, namely 118 subjects in the non-caries (NC) group and severe early childhood caries (S-ECC) group, respectively. Oral mucosa cells were collected from all the selected children, and the full length of exon 3 in TAS1R2 was sequenced to analyse rs35874116 polymorphism. A questionnaire was used to collect information about socio-demographic information, frequency of sweet intake and oral hygiene habits. Multiple logistic regression models were applied to assess the relationship of rs35874116 polymorphism with frequency of sweet intake and S-ECC among the five-year-old children. Results Children with the TT genotype of rs35874116 had a higher frequency of sweet intake than CT/CC carriers (51.3% vs. 32.7%; x 2 = 5.436, p = 0.020), and S-ECC individuals were more likely to be TT genotype carriers than NC individuals (53.5% vs. 46.5%; x 2 = 4.353, p = 0.037). Multiple logistic regression analyses showed that the TT genotype of rs35874116 was not only significantly related to the frequency of sweet intake (OR = 2.25, 95% CI = 1.14–4.44) but also significantly associated with S-ECC (OR = 2.11, 95% CI = 1.01 ~ 4.42). Conclusions The rs35874116 polymorphism might increase sweet intake and the risk of S-ECC among five-year-old children in Nanning, China. |
| first_indexed | 2024-04-13T15:36:19Z |
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| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-13T15:36:19Z |
| publishDate | 2022-11-01 |
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| series | BMC Oral Health |
| spelling | doaj.art-2884c096f4f840c4954073645ba8c1ad2022-12-22T02:41:15ZengBMCBMC Oral Health1472-68312022-11-012211810.1186/s12903-022-02512-8The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control studyYan Liang0Junyu Yao1Rongmin Qiu2Aihua Chen3Hua Huang4Huancai Lin5Lixia Yu6College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious DiseasesDepartment of Preventive Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologyDepartment of Preventive Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologyAbstract Background Dental caries is one of the most prevalent chronic diseases worldwide among children. The rs35874116 single nucleotide polymorphism (SNP) in the sweet receptor gene TAS1R2 has been associated with dental caries at a high risk in permanent teeth among school children and adults. To date, little is known about the association of this SNP with sweet intake and caries risk in the primary school children. Methods Total of 236 children were included, namely 118 subjects in the non-caries (NC) group and severe early childhood caries (S-ECC) group, respectively. Oral mucosa cells were collected from all the selected children, and the full length of exon 3 in TAS1R2 was sequenced to analyse rs35874116 polymorphism. A questionnaire was used to collect information about socio-demographic information, frequency of sweet intake and oral hygiene habits. Multiple logistic regression models were applied to assess the relationship of rs35874116 polymorphism with frequency of sweet intake and S-ECC among the five-year-old children. Results Children with the TT genotype of rs35874116 had a higher frequency of sweet intake than CT/CC carriers (51.3% vs. 32.7%; x 2 = 5.436, p = 0.020), and S-ECC individuals were more likely to be TT genotype carriers than NC individuals (53.5% vs. 46.5%; x 2 = 4.353, p = 0.037). Multiple logistic regression analyses showed that the TT genotype of rs35874116 was not only significantly related to the frequency of sweet intake (OR = 2.25, 95% CI = 1.14–4.44) but also significantly associated with S-ECC (OR = 2.11, 95% CI = 1.01 ~ 4.42). Conclusions The rs35874116 polymorphism might increase sweet intake and the risk of S-ECC among five-year-old children in Nanning, China.https://doi.org/10.1186/s12903-022-02512-8Single nucleotide polymorphismSweet receptor geneSweet intakeSevere early childhood caries |
| spellingShingle | Yan Liang Junyu Yao Rongmin Qiu Aihua Chen Hua Huang Huancai Lin Lixia Yu The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study BMC Oral Health Single nucleotide polymorphism Sweet receptor gene Sweet intake Severe early childhood caries |
| title | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study |
| title_full | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study |
| title_fullStr | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study |
| title_full_unstemmed | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study |
| title_short | The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case–control study |
| title_sort | rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries a case control study |
| topic | Single nucleotide polymorphism Sweet receptor gene Sweet intake Severe early childhood caries |
| url | https://doi.org/10.1186/s12903-022-02512-8 |
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