Lung T cell response in COVID-19
The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory response in driving both the resolution of the dise...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108716/full |
| _version_ | 1797905242117898240 |
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| author | Mehrnoush Hadaddzadeh Shakiba Mehrnoush Hadaddzadeh Shakiba Ioanna Gemünd Ioanna Gemünd Ioanna Gemünd Marc Beyer Marc Beyer Marc Beyer Lorenzo Bonaguro Lorenzo Bonaguro |
| author_facet | Mehrnoush Hadaddzadeh Shakiba Mehrnoush Hadaddzadeh Shakiba Ioanna Gemünd Ioanna Gemünd Ioanna Gemünd Marc Beyer Marc Beyer Marc Beyer Lorenzo Bonaguro Lorenzo Bonaguro |
| author_sort | Mehrnoush Hadaddzadeh Shakiba |
| collection | DOAJ |
| description | The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory response in driving both the resolution of the disease and uncontrolled deleterious inflammatory status in severe cases. In this mini-review, we cover some important aspects of the role of T cells in COVID-19 with a special focus on the local response in the lung. We focus on the reported T cell phenotypes in mild, moderate, and severe COVID-19, focusing on lung inflammation and on both the protective and damaging roles of the T cell response, also highlighting the open questions in the field. |
| first_indexed | 2024-04-10T10:02:01Z |
| format | Article |
| id | doaj.art-28853a6170594930901ab311a0b71d3d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T10:02:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-28853a6170594930901ab311a0b71d3d2023-02-16T06:15:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11087161108716Lung T cell response in COVID-19Mehrnoush Hadaddzadeh Shakiba0Mehrnoush Hadaddzadeh Shakiba1Ioanna Gemünd2Ioanna Gemünd3Ioanna Gemünd4Marc Beyer5Marc Beyer6Marc Beyer7Lorenzo Bonaguro8Lorenzo Bonaguro9Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyImmunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanySystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyGenomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, GermanyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, AustraliaSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyImmunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyPRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and University of Bonn, Bonn, GermanySystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyGenomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, GermanyThe COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory response in driving both the resolution of the disease and uncontrolled deleterious inflammatory status in severe cases. In this mini-review, we cover some important aspects of the role of T cells in COVID-19 with a special focus on the local response in the lung. We focus on the reported T cell phenotypes in mild, moderate, and severe COVID-19, focusing on lung inflammation and on both the protective and damaging roles of the T cell response, also highlighting the open questions in the field.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108716/fullT-cellCOVID-19SARS-CoV-2pathomechanismlung |
| spellingShingle | Mehrnoush Hadaddzadeh Shakiba Mehrnoush Hadaddzadeh Shakiba Ioanna Gemünd Ioanna Gemünd Ioanna Gemünd Marc Beyer Marc Beyer Marc Beyer Lorenzo Bonaguro Lorenzo Bonaguro Lung T cell response in COVID-19 Frontiers in Immunology T-cell COVID-19 SARS-CoV-2 pathomechanism lung |
| title | Lung T cell response in COVID-19 |
| title_full | Lung T cell response in COVID-19 |
| title_fullStr | Lung T cell response in COVID-19 |
| title_full_unstemmed | Lung T cell response in COVID-19 |
| title_short | Lung T cell response in COVID-19 |
| title_sort | lung t cell response in covid 19 |
| topic | T-cell COVID-19 SARS-CoV-2 pathomechanism lung |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108716/full |
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