Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours
Cardiotoxicity is a well-recognised side effect of cancer-related therapies with a great impact on outcomes and quality of life in the cancer survivor population. The pathogenesis of chemotherapy-induced cardiotoxicity in patients with gastrointestinal cancers involves various molecular mechanisms,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/806 |
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| author | Liliana Maria Radulescu Dan Radulescu Tudor-Eliade Ciuleanu Dana Crisan Elena Buzdugan Dragos-Mihai Romitan Anca Dana Buzoianu |
| author_facet | Liliana Maria Radulescu Dan Radulescu Tudor-Eliade Ciuleanu Dana Crisan Elena Buzdugan Dragos-Mihai Romitan Anca Dana Buzoianu |
| author_sort | Liliana Maria Radulescu |
| collection | DOAJ |
| description | Cardiotoxicity is a well-recognised side effect of cancer-related therapies with a great impact on outcomes and quality of life in the cancer survivor population. The pathogenesis of chemotherapy-induced cardiotoxicity in patients with gastrointestinal cancers involves various molecular mechanisms, and the combined use of various chemotherapies augments the risk of each drug used alone. In terms of cardiotoxicity diagnosis, novel biomarkers, such as troponins, brain natriuretic peptide (BNP), myeloperoxidases and miRNAs have been recently assessed. Echocardiography is a noninvasive imaging method of choice for the primary assessment of chemotherapy-treated patients to generally evaluate the cardiovascular impact of these drugs. Novel echocardiography techniques, like three-dimensional and stress echocardiography, will improve diagnosis efficacy. Cardiac magnetic resonance (CMR) can evaluate cardiac morphology, function and wall structure. Corroborated data have shown the importance of CMR in the early evaluation of patients with gastrointestinal cancers, treated with anticancer drugs, but further studies are required to improve risk stratification in these patients. In this article, we review some important aspects concerning the cardiotoxicity of antineoplastic drugs used in gastrointestinal cancers. We also discuss the mechanism of cardiotoxicity, the role of biomarkers and the imaging methods used in its detection. |
| first_indexed | 2024-03-10T08:36:49Z |
| format | Article |
| id | doaj.art-28867fd9d93f4cb2aecf92c9e8ccdebc |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:36:49Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-28867fd9d93f4cb2aecf92c9e8ccdebc2023-11-22T08:36:23ZengMDPI AGMedicina1010-660X1648-91442021-08-0157880610.3390/medicina57080806Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal TumoursLiliana Maria Radulescu0Dan Radulescu1Tudor-Eliade Ciuleanu2Dana Crisan3Elena Buzdugan4Dragos-Mihai Romitan5Anca Dana Buzoianu6Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hațieganu University of Medicine and Pharmacy, 400005 Cluj-Napoca, RomaniaDepartment of Cardiology, Cluj Municipal Hospital, 400005 Cluj-Napoca, RomaniaDepartment of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaDepartment of Internal Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, 400005 Cluj-Napoca, RomaniaDepartment of Cardiology, Cluj Municipal Hospital, 400005 Cluj-Napoca, RomaniaDepartment of Cardiology, Cluj Municipal Hospital, 400005 Cluj-Napoca, RomaniaDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hațieganu University of Medicine and Pharmacy, 400005 Cluj-Napoca, RomaniaCardiotoxicity is a well-recognised side effect of cancer-related therapies with a great impact on outcomes and quality of life in the cancer survivor population. The pathogenesis of chemotherapy-induced cardiotoxicity in patients with gastrointestinal cancers involves various molecular mechanisms, and the combined use of various chemotherapies augments the risk of each drug used alone. In terms of cardiotoxicity diagnosis, novel biomarkers, such as troponins, brain natriuretic peptide (BNP), myeloperoxidases and miRNAs have been recently assessed. Echocardiography is a noninvasive imaging method of choice for the primary assessment of chemotherapy-treated patients to generally evaluate the cardiovascular impact of these drugs. Novel echocardiography techniques, like three-dimensional and stress echocardiography, will improve diagnosis efficacy. Cardiac magnetic resonance (CMR) can evaluate cardiac morphology, function and wall structure. Corroborated data have shown the importance of CMR in the early evaluation of patients with gastrointestinal cancers, treated with anticancer drugs, but further studies are required to improve risk stratification in these patients. In this article, we review some important aspects concerning the cardiotoxicity of antineoplastic drugs used in gastrointestinal cancers. We also discuss the mechanism of cardiotoxicity, the role of biomarkers and the imaging methods used in its detection.https://www.mdpi.com/1648-9144/57/8/806gastrointestinal cancercardiotoxicityechocardiographycardiac magnetic resonance imaging |
| spellingShingle | Liliana Maria Radulescu Dan Radulescu Tudor-Eliade Ciuleanu Dana Crisan Elena Buzdugan Dragos-Mihai Romitan Anca Dana Buzoianu Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours Medicina gastrointestinal cancer cardiotoxicity echocardiography cardiac magnetic resonance imaging |
| title | Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours |
| title_full | Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours |
| title_fullStr | Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours |
| title_full_unstemmed | Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours |
| title_short | Cardiotoxicity Associated with Chemotherapy Used in Gastrointestinal Tumours |
| title_sort | cardiotoxicity associated with chemotherapy used in gastrointestinal tumours |
| topic | gastrointestinal cancer cardiotoxicity echocardiography cardiac magnetic resonance imaging |
| url | https://www.mdpi.com/1648-9144/57/8/806 |
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