Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs
The development of new anti-cancer agents is an urgent necessity nowadays, as it is one of the major causes of mortality worldwide. Many drugs currently used are derived from natural products. Halimanes are a class of bicyclic diterpenoids present in various plants and microorganisms. Many of them e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1225355/full |
| _version_ | 1797739599136555008 |
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| author | Alejandro M. Roncero Ignacio E. Tobal Rosalina F. Moro David Diez Isidro S. Marcos |
| author_facet | Alejandro M. Roncero Ignacio E. Tobal Rosalina F. Moro David Diez Isidro S. Marcos |
| author_sort | Alejandro M. Roncero |
| collection | DOAJ |
| description | The development of new anti-cancer agents is an urgent necessity nowadays, as it is one of the major causes of mortality worldwide. Many drugs currently used are derived from natural products. Halimanes are a class of bicyclic diterpenoids present in various plants and microorganisms. Many of them exhibit biological activities such as antitumor, antimicrobial, or anti-inflammatory. Among them, ent-halimic acid is an easily accessible compound, in large quantities, from the ethyl acetate extract of the plant Halimium viscosum, and it has been used as a starting material in a number of bioactive molecules. In this work, we review all the natural halimanes with antitumor and related activities until date as well as the synthesis of antitumor compounds using ent-halimic acid as a starting material. |
| first_indexed | 2024-03-12T14:00:30Z |
| format | Article |
| id | doaj.art-28869f3e716b451884e2ed44b57ece13 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-12T14:00:30Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-28869f3e716b451884e2ed44b57ece132023-08-22T07:12:19ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-08-011110.3389/fchem.2023.12253551225355Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugsAlejandro M. RonceroIgnacio E. TobalRosalina F. MoroDavid DiezIsidro S. MarcosThe development of new anti-cancer agents is an urgent necessity nowadays, as it is one of the major causes of mortality worldwide. Many drugs currently used are derived from natural products. Halimanes are a class of bicyclic diterpenoids present in various plants and microorganisms. Many of them exhibit biological activities such as antitumor, antimicrobial, or anti-inflammatory. Among them, ent-halimic acid is an easily accessible compound, in large quantities, from the ethyl acetate extract of the plant Halimium viscosum, and it has been used as a starting material in a number of bioactive molecules. In this work, we review all the natural halimanes with antitumor and related activities until date as well as the synthesis of antitumor compounds using ent-halimic acid as a starting material.https://www.frontiersin.org/articles/10.3389/fchem.2023.1225355/fullhalimanesent-halimic acidantitumorditerpenescancernatural products |
| spellingShingle | Alejandro M. Roncero Ignacio E. Tobal Rosalina F. Moro David Diez Isidro S. Marcos Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs Frontiers in Chemistry halimanes ent-halimic acid antitumor diterpenes cancer natural products |
| title | Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs |
| title_full | Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs |
| title_fullStr | Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs |
| title_full_unstemmed | Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs |
| title_short | Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs |
| title_sort | halimanes and cancer ent halimic acid as a starting material for the synthesis of antitumor drugs |
| topic | halimanes ent-halimic acid antitumor diterpenes cancer natural products |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1225355/full |
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