Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan
This study investigated the relationship between grey matter (GM) volume and blood biomarkers, blood pressure, and obesity. We aimed to elucidate lifestyle factors that promote GM volume loss. A total of 1799 participants underwent the brain dock as a medical checkup. Data regarding blood pressure,...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/2973 |
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| author | Keita Watanabe Shingo Kakeda Kiyotaka Nemoto Keiichi Onoda Shuhei Yamaguchi Shotai Kobayashi Yoshinori Yamakawa |
| author_facet | Keita Watanabe Shingo Kakeda Kiyotaka Nemoto Keiichi Onoda Shuhei Yamaguchi Shotai Kobayashi Yoshinori Yamakawa |
| author_sort | Keita Watanabe |
| collection | DOAJ |
| description | This study investigated the relationship between grey matter (GM) volume and blood biomarkers, blood pressure, and obesity. We aimed to elucidate lifestyle factors that promote GM volume loss. A total of 1799 participants underwent the brain dock as a medical checkup. Data regarding blood pressure, obesity measurements, and standard blood biomarkers were obtained. Further, brain magnetic resonance imaging (MRI), including high-resolution T1-weighted imaging, was performed. We calculated the grey matter brain healthcare quotient (GM-BHQ), which represents GM volume as a deviation value. After adjusting for confounding variables, multiple regression analysis revealed that body mass index (BMI) (<i>b</i> = −0.28, <i>p</i> < 0.001), gamma-glutamyltransferase (γ-GTP) (<i>b</i> = −0.01, <i>p</i> = 0.16), and fasting blood glucose (<i>b</i> = −0.02, <i>p</i> = 0.049) were significantly correlated with GM-BHQ. Although the current cross-sectional study cannot determine a cause-and-effect relationship, elevated BMI, γ-GTP, and fasting blood glucose could promote GM volume loss. |
| first_indexed | 2024-03-10T01:12:58Z |
| format | Article |
| id | doaj.art-2887123a80d143238dfcb301b47bd530 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:12:58Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2887123a80d143238dfcb301b47bd5302023-11-23T14:14:39ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011111297310.3390/jcm11112973Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in JapanKeita Watanabe0Shingo Kakeda1Kiyotaka Nemoto2Keiichi Onoda3Shuhei Yamaguchi4Shotai Kobayashi5Yoshinori Yamakawa6Institution of Open Innovation, Kyoto University, Kyoto 606-8501, JapanDepartment of Diagnostic Radiology, Hirosaki University Graduate School of Medicine Radiology, Aomori 036-8562, JapanDivision of Clinical Medicine, Department of Neuropsychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, JapanDepartment of Psychology, Otemon Gakuin University, Osaka 567-8502, JapanDepartment of Neurology, Shimane University, Izumo 690-0823, JapanDepartment of Neurology, Shimane University, Izumo 690-0823, JapanInstitution of Open Innovation, Kyoto University, Kyoto 606-8501, JapanThis study investigated the relationship between grey matter (GM) volume and blood biomarkers, blood pressure, and obesity. We aimed to elucidate lifestyle factors that promote GM volume loss. A total of 1799 participants underwent the brain dock as a medical checkup. Data regarding blood pressure, obesity measurements, and standard blood biomarkers were obtained. Further, brain magnetic resonance imaging (MRI), including high-resolution T1-weighted imaging, was performed. We calculated the grey matter brain healthcare quotient (GM-BHQ), which represents GM volume as a deviation value. After adjusting for confounding variables, multiple regression analysis revealed that body mass index (BMI) (<i>b</i> = −0.28, <i>p</i> < 0.001), gamma-glutamyltransferase (γ-GTP) (<i>b</i> = −0.01, <i>p</i> = 0.16), and fasting blood glucose (<i>b</i> = −0.02, <i>p</i> = 0.049) were significantly correlated with GM-BHQ. Although the current cross-sectional study cannot determine a cause-and-effect relationship, elevated BMI, γ-GTP, and fasting blood glucose could promote GM volume loss.https://www.mdpi.com/2077-0383/11/11/2973MRIGM-BHQGM volumeBMIblood biomarkerblood pressure |
| spellingShingle | Keita Watanabe Shingo Kakeda Kiyotaka Nemoto Keiichi Onoda Shuhei Yamaguchi Shotai Kobayashi Yoshinori Yamakawa Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan Journal of Clinical Medicine MRI GM-BHQ GM volume BMI blood biomarker blood pressure |
| title | Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan |
| title_full | Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan |
| title_fullStr | Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan |
| title_full_unstemmed | Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan |
| title_short | Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan |
| title_sort | effects of obesity blood pressure and blood metabolic biomarkers on grey matter brain healthcare quotient a large cohort study of a magnetic resonance imaging brain screening system in japan |
| topic | MRI GM-BHQ GM volume BMI blood biomarker blood pressure |
| url | https://www.mdpi.com/2077-0383/11/11/2973 |
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