Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex
Pudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=4;spage=676;epage=681;aulast=Ju |
| _version_ | 1818883908027023360 |
|---|---|
| author | Yan-he Ju Li-min Liao |
| author_facet | Yan-he Ju Li-min Liao |
| author_sort | Yan-he Ju |
| collection | DOAJ |
| description | Pudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve. This study explored the excitatory pudendal-to-bladder reflex in beagle dogs, with intact or injured spinal cord, by electrical stimulation of the pudendal nerve trunk. The optimal stimulation frequency was approximately 15-25 Hz. This excitatory effect was dependent to some extent on the bladder volume. We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function. |
| first_indexed | 2024-12-19T15:41:07Z |
| format | Article |
| id | doaj.art-28886ce355fe4310898b9a6548d98017 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T15:41:07Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-28886ce355fe4310898b9a6548d980172022-12-21T20:15:27ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111467668110.4103/1673-5374.180757Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflexYan-he JuLi-min LiaoPudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve. This study explored the excitatory pudendal-to-bladder reflex in beagle dogs, with intact or injured spinal cord, by electrical stimulation of the pudendal nerve trunk. The optimal stimulation frequency was approximately 15-25 Hz. This excitatory effect was dependent to some extent on the bladder volume. We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=4;spage=676;epage=681;aulast=Junerve regeneration; pudendal nerve; neurogenic bladder; spinal cord injury; electrical stimulation; urodynamics; voiding reflex; neuromodulation; neural regeneration |
| spellingShingle | Yan-he Ju Li-min Liao Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex Neural Regeneration Research nerve regeneration; pudendal nerve; neurogenic bladder; spinal cord injury; electrical stimulation; urodynamics; voiding reflex; neuromodulation; neural regeneration |
| title | Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex |
| title_full | Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex |
| title_fullStr | Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex |
| title_full_unstemmed | Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex |
| title_short | Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex |
| title_sort | electrical stimulation of dog pudendal nerve regulates the excitatory pudendal to bladder reflex |
| topic | nerve regeneration; pudendal nerve; neurogenic bladder; spinal cord injury; electrical stimulation; urodynamics; voiding reflex; neuromodulation; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=4;spage=676;epage=681;aulast=Ju |
| work_keys_str_mv | AT yanheju electricalstimulationofdogpudendalnerveregulatestheexcitatorypudendaltobladderreflex AT liminliao electricalstimulationofdogpudendalnerveregulatestheexcitatorypudendaltobladderreflex |