DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes

DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes

Abstract Background Molecular subtyping of urothelial cancer (UC) has significantly advanced the understanding of bladder tumor heterogeneity and development of prognostic and predictive biomarkers. Evolving evidence across cancers strongly suggests that tumor immunoediting has a profound impact on...

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Bibliographic Details
Main Authors: Thiago Vidotto, Sarah Nersesian, Charles Graham, D. Robert Siemens, Madhuri Koti
Format: Article
Language:English
Published: BMJ Publishing Group 2019-06-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Bladder Cancer
Interferon
DNA damage repair
Immune checkpoint
Online Access:http://link.springer.com/article/10.1186/s40425-019-0619-8

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