Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis

Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis

Abstract Matrix metalloproteinase (MMP) activity is tightly regulated by the endogenous tissue inhibitors (TIMPs), and dysregulated activity contributes to extracellular matrix remodelling. Accordingly, MMP/TIMP balance is associated with atherosclerotic plaque progression and instability, alongside...

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Bibliographic Details
Main Authors:	Georgios Kremastiotis, Ishita Handa, Christopher Jackson, Sarah George, Jason Johnson
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-11-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-02508-4

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