Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure
Background: Continuous light exposure increases sympathetic excitation in rats, leading to hypertension, left ventricular hypertrophy, and fibrosis. This study was aimed to investigate whether continuous light exposure causes destabilization of vital signs and gut microbiota (GM) in Sprague Dawley (...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023099504 |
| _version_ | 1797337078533455872 |
|---|---|
| author | Yi Zhao Xu-ming Ma Ming Ren Huiqin Liu Hao-liang Duan Xing-li Liu Zhong-shan Gao Yu-lan Ma |
| author_facet | Yi Zhao Xu-ming Ma Ming Ren Huiqin Liu Hao-liang Duan Xing-li Liu Zhong-shan Gao Yu-lan Ma |
| author_sort | Yi Zhao |
| collection | DOAJ |
| description | Background: Continuous light exposure increases sympathetic excitation in rats, leading to hypertension, left ventricular hypertrophy, and fibrosis. This study was aimed to investigate whether continuous light exposure causes destabilization of vital signs and gut microbiota (GM) in Sprague Dawley (SD) rats and whether clonidine hydrochloride (CH), a central sympathetic depressant drug, could prevent these changes. Methods: Eight-week-old male SD rats were divided into three groups with different interventions for 14 weeks: control group (CG), 2-mL pure water gavaged daily while on a normal 12-h light/dark cycle; continuous illumination group (CI), 2-mL pure water gavaged daily while receiving continuous exposure to light (300 lx); and drug administration group (DA), CH (10 μg/kg) gavaged daily while receiving continuous exposure to light (300 lx). Results: The results showed that blood pressure, heart rate, and body weight were significantly higher in the CI group than in the CG and DA groups (P < 0.05). Moreover, the Shannon index was higher in the DA group than in the CI group (P = 0.012). The beta diversity index in the CG group was significantly higher in the CI group (P = 0.039). The pairwise comparison results of the linear discriminant analysis effect size showed that Oscillospirales were enriched in the DA group, whereas the Prevotellaceae lineage (family level) > Prevotella (genus level) > Prevotellaceae_bacterium (species level) were enriched in the CI group. The Muribaculaceae family was more abundant in the CG group than in the CI group. Conclusion: Sympathetic nerve inhibition restored the abnormal vital signs and GM changes under continuous light exposure. |
| first_indexed | 2024-03-08T09:04:12Z |
| format | Article |
| id | doaj.art-288d8df3bbf6439ea9ab72fdbb14dcc2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:04:12Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-288d8df3bbf6439ea9ab72fdbb14dcc22024-02-01T06:30:14ZengElsevierHeliyon2405-84402024-01-01101e22742Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposureYi Zhao0Xu-ming Ma1Ming Ren2Huiqin Liu3Hao-liang Duan4Xing-li Liu5Zhong-shan Gao6Yu-lan Ma7Qinghai University, Xining 810001, ChinaDepartment of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, ChinaDepartment of Cardiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, ChinaDepartment of Cardiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, ChinaQinghai University, Xining 810001, ChinaQinghai University, Xining 810001, ChinaQinghai University, Xining 810001, ChinaDepartment of Cardiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China; Corresponding author.Background: Continuous light exposure increases sympathetic excitation in rats, leading to hypertension, left ventricular hypertrophy, and fibrosis. This study was aimed to investigate whether continuous light exposure causes destabilization of vital signs and gut microbiota (GM) in Sprague Dawley (SD) rats and whether clonidine hydrochloride (CH), a central sympathetic depressant drug, could prevent these changes. Methods: Eight-week-old male SD rats were divided into three groups with different interventions for 14 weeks: control group (CG), 2-mL pure water gavaged daily while on a normal 12-h light/dark cycle; continuous illumination group (CI), 2-mL pure water gavaged daily while receiving continuous exposure to light (300 lx); and drug administration group (DA), CH (10 μg/kg) gavaged daily while receiving continuous exposure to light (300 lx). Results: The results showed that blood pressure, heart rate, and body weight were significantly higher in the CI group than in the CG and DA groups (P < 0.05). Moreover, the Shannon index was higher in the DA group than in the CI group (P = 0.012). The beta diversity index in the CG group was significantly higher in the CI group (P = 0.039). The pairwise comparison results of the linear discriminant analysis effect size showed that Oscillospirales were enriched in the DA group, whereas the Prevotellaceae lineage (family level) > Prevotella (genus level) > Prevotellaceae_bacterium (species level) were enriched in the CI group. The Muribaculaceae family was more abundant in the CG group than in the CI group. Conclusion: Sympathetic nerve inhibition restored the abnormal vital signs and GM changes under continuous light exposure.http://www.sciencedirect.com/science/article/pii/S2405844023099504Continuous light exposureGut microbiotaSympathetic nerveCardiovascular diseaseCircadian rhythm disruption |
| spellingShingle | Yi Zhao Xu-ming Ma Ming Ren Huiqin Liu Hao-liang Duan Xing-li Liu Zhong-shan Gao Yu-lan Ma Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure Heliyon Continuous light exposure Gut microbiota Sympathetic nerve Cardiovascular disease Circadian rhythm disruption |
| title | Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| title_full | Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| title_fullStr | Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| title_full_unstemmed | Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| title_short | Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| title_sort | central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure |
| topic | Continuous light exposure Gut microbiota Sympathetic nerve Cardiovascular disease Circadian rhythm disruption |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023099504 |
| work_keys_str_mv | AT yizhao centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT xumingma centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT mingren centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT huiqinliu centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT haoliangduan centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT xingliliu centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT zhongshangao centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure AT yulanma centralblockageofsympatheticnervesinhibitstheabnormalvitalsignsanddisturbanceofthegutmicrobiotacausedbycontinuouslightexposure |