Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies
Summary Sex differences in symptomatology in people with psychosis have been studied extensively in recent decades. Although studies have pointed to such differences, to date there is no review that has performed a systematic search and quantitative synthesis. In this paper, we describe the protocol...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-11-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472422005968/type/journal_article |
| _version_ | 1811156837979914240 |
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| author | Marta Ferrer-Quintero Marina Verdaguer-Rodriguez Marina Esteban Sanjusto Clara Serra-Arumí Judith Usall Susana Ochoa Irene Bighelli Helena García-Mieres |
| author_facet | Marta Ferrer-Quintero Marina Verdaguer-Rodriguez Marina Esteban Sanjusto Clara Serra-Arumí Judith Usall Susana Ochoa Irene Bighelli Helena García-Mieres |
| author_sort | Marta Ferrer-Quintero |
| collection | DOAJ |
| description | Summary
Sex differences in symptomatology in people with psychosis have been studied extensively in recent decades. Although studies have pointed to such differences, to date there is no review that has performed a systematic search and quantitative synthesis. In this paper, we describe the protocol for a pairwise meta-analysis comparing a range of symptom outcome measures between men and women diagnosed with a psychotic spectrum disorder at different stages of the disorder (PROSPERO registration number CRD42021264942). In August 2021 we conducted systematic searches of PsychInfo, PubMed, Web of Science, Scopus and Dialnet to identify observational studies that report data on symptoms for males and females separately. Two independent reviewers will conduct literature searches, select studies, extract data, assess the risk of bias and assess outcome quality. To assess the effect size of all outcome measures, we will conduct pairwise meta-analysis using random-effects models. The quality of studies will be evaluated using a National Heart, Lung and Blood Institute's quality assessment tool and the confidence in the results will be evaluated using the GRADE tool. Meta-regression and sensitivity analyses will be conducted to assess the robustness of the findings. No ethical problems are foreseen. Results from this study will be published in peer-reviewed journals and presented at relevant conferences.
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| first_indexed | 2024-04-10T04:57:45Z |
| format | Article |
| id | doaj.art-288df9443e784e6786ad8b5ed0e03103 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:57:45Z |
| publishDate | 2022-11-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-288df9443e784e6786ad8b5ed0e031032023-03-09T12:29:24ZengCambridge University PressBJPsych Open2056-47242022-11-01810.1192/bjo.2022.596Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studiesMarta Ferrer-Quintero0Marina Verdaguer-Rodriguez1Marina Esteban Sanjusto2Clara Serra-Arumí3Judith Usall4Susana Ochoa5Irene Bighelli6Helena García-Mieres7https://orcid.org/0000-0002-2813-1737Institut de Recerca Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; and Departament de Psicología Social i Quantitativa, Universitat de Barcelona, SpainInstitut de Recerca Sant Joan de Déu, Barcelona, SpainInstitut de Recerca Sant Joan de Déu, Barcelona, SpainInstitut de Recerca Sant Joan de Déu, Barcelona, SpainInstitut de Recerca Sant Joan de Déu, Barcelona, SpainInstitut de Recerca Sant Joan de Déu, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainDepartment of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, GermanyInstitut de Recerca Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Health Services Research Unit, Institut Hospital del Mar de Investigacions Médiques (IMIM), Barcelona, Spain; and Department of Medicine and Health Sciences, Universitat Pompeu Fabra, Barcelona, SpainSummary Sex differences in symptomatology in people with psychosis have been studied extensively in recent decades. Although studies have pointed to such differences, to date there is no review that has performed a systematic search and quantitative synthesis. In this paper, we describe the protocol for a pairwise meta-analysis comparing a range of symptom outcome measures between men and women diagnosed with a psychotic spectrum disorder at different stages of the disorder (PROSPERO registration number CRD42021264942). In August 2021 we conducted systematic searches of PsychInfo, PubMed, Web of Science, Scopus and Dialnet to identify observational studies that report data on symptoms for males and females separately. Two independent reviewers will conduct literature searches, select studies, extract data, assess the risk of bias and assess outcome quality. To assess the effect size of all outcome measures, we will conduct pairwise meta-analysis using random-effects models. The quality of studies will be evaluated using a National Heart, Lung and Blood Institute's quality assessment tool and the confidence in the results will be evaluated using the GRADE tool. Meta-regression and sensitivity analyses will be conducted to assess the robustness of the findings. No ethical problems are foreseen. Results from this study will be published in peer-reviewed journals and presented at relevant conferences. https://www.cambridge.org/core/product/identifier/S2056472422005968/type/journal_articleSex differencesschizophreniafirst-episode psychosisultra-high risk for psychosissymptoms |
| spellingShingle | Marta Ferrer-Quintero Marina Verdaguer-Rodriguez Marina Esteban Sanjusto Clara Serra-Arumí Judith Usall Susana Ochoa Irene Bighelli Helena García-Mieres Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies BJPsych Open Sex differences schizophrenia first-episode psychosis ultra-high risk for psychosis symptoms |
| title | Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies |
| title_full | Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies |
| title_fullStr | Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies |
| title_full_unstemmed | Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies |
| title_short | Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies |
| title_sort | sex differences in symptomatology in people with schizophrenia and other psychotic disorders protocol for a systematic review and pairwise meta analysis of observational studies |
| topic | Sex differences schizophrenia first-episode psychosis ultra-high risk for psychosis symptoms |
| url | https://www.cambridge.org/core/product/identifier/S2056472422005968/type/journal_article |
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