Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles
Objective: The aim of this study was to assess whether the early blastulation (EB) of day 4 embryo is a useful predictor for outcomes in fresh elective single embryo transfer (eSET) cycles. Materials and methods: We retrospectively enrolled patients undergoing fresh SET cycles in our hospital from A...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455918301839 |
| _version_ | 1819264654230159360 |
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| author | Cheng-En Hsieh Robert Kuo-Kuang Lee Fang-Ju Sun Ryh-Sheng Li Shyr-Yeu Lin Ming-Huei Lin Yuh-Ming Hwu |
| author_facet | Cheng-En Hsieh Robert Kuo-Kuang Lee Fang-Ju Sun Ryh-Sheng Li Shyr-Yeu Lin Ming-Huei Lin Yuh-Ming Hwu |
| author_sort | Cheng-En Hsieh |
| collection | DOAJ |
| description | Objective: The aim of this study was to assess whether the early blastulation (EB) of day 4 embryo is a useful predictor for outcomes in fresh elective single embryo transfer (eSET) cycles. Materials and methods: We retrospectively enrolled patients undergoing fresh SET cycles in our hospital from April 2014 to September 2016 and met with the following criteria: 1) age <38 years, 2) first IVF/ICSI cycle, 3) at least two blastocysts with morphological grading better than or equal to 4BB. Results: A total of 81 patients were included. Of whom, 55 patients (68%) had undergone eSET with embryos that had early blastulation on day 4 while the other 26 patients had had no EB. Early blastulation has shown a higher rate of good blastocyst (84.3% vs. 60.5%, p < 0.0001). The clinical pregnancy rate of EB group was significantly higher than that of non-EB group (56.4% vs. 27.0%, p = 0.013). There is also a tendency in EB group to have a lower abortion rate (3.23% vs. 28.6%, p = 0.081). Conclusions: EB on day 4 is a useful predictor of the quality of the following embryos (i.e. day 5 embryo). It is a simple tool in selecting the best embryo to get a higher pregnancy rate in fresh eSET cycles.Trial registration: This study was supplementally registered by the MacKay Memorial Hospital Institutional Review Board on April 18, 2017 (registration No. 17MMHIS039e). Keywords: Early blastulation, Single-embryo transfer, Blastocyst morphology, Clinical pregnancy |
| first_indexed | 2024-12-23T20:32:55Z |
| format | Article |
| id | doaj.art-28902875e75b484aa35678dbad14ca9f |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-23T20:32:55Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-28902875e75b484aa35678dbad14ca9f2022-12-21T17:32:10ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592018-10-01575705708Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cyclesCheng-En Hsieh0Robert Kuo-Kuang Lee1Fang-Ju Sun2Ryh-Sheng Li3Shyr-Yeu Lin4Ming-Huei Lin5Yuh-Ming Hwu6Department of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Medical University, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taiwan; Corresponding author. No. 92, Sec. 2, Zhong-Shan North Road, Zhong-Shan Dist., 10449, New Taipei City, Taiwan. Fax: +886 2 25433642.Department of Medical Research, MacKay Memorial Hospital, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; MacKay Medical College, New Taipei City, TaiwanDepartment of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; MacKay Medical College, New Taipei City, TaiwanObjective: The aim of this study was to assess whether the early blastulation (EB) of day 4 embryo is a useful predictor for outcomes in fresh elective single embryo transfer (eSET) cycles. Materials and methods: We retrospectively enrolled patients undergoing fresh SET cycles in our hospital from April 2014 to September 2016 and met with the following criteria: 1) age <38 years, 2) first IVF/ICSI cycle, 3) at least two blastocysts with morphological grading better than or equal to 4BB. Results: A total of 81 patients were included. Of whom, 55 patients (68%) had undergone eSET with embryos that had early blastulation on day 4 while the other 26 patients had had no EB. Early blastulation has shown a higher rate of good blastocyst (84.3% vs. 60.5%, p < 0.0001). The clinical pregnancy rate of EB group was significantly higher than that of non-EB group (56.4% vs. 27.0%, p = 0.013). There is also a tendency in EB group to have a lower abortion rate (3.23% vs. 28.6%, p = 0.081). Conclusions: EB on day 4 is a useful predictor of the quality of the following embryos (i.e. day 5 embryo). It is a simple tool in selecting the best embryo to get a higher pregnancy rate in fresh eSET cycles.Trial registration: This study was supplementally registered by the MacKay Memorial Hospital Institutional Review Board on April 18, 2017 (registration No. 17MMHIS039e). Keywords: Early blastulation, Single-embryo transfer, Blastocyst morphology, Clinical pregnancyhttp://www.sciencedirect.com/science/article/pii/S1028455918301839 |
| spellingShingle | Cheng-En Hsieh Robert Kuo-Kuang Lee Fang-Ju Sun Ryh-Sheng Li Shyr-Yeu Lin Ming-Huei Lin Yuh-Ming Hwu Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles Taiwanese Journal of Obstetrics & Gynecology |
| title | Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles |
| title_full | Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles |
| title_fullStr | Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles |
| title_full_unstemmed | Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles |
| title_short | Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles |
| title_sort | early blastulation eb of day 4 embryo is predictive of outcomes in single embryo transfer set cycles |
| url | http://www.sciencedirect.com/science/article/pii/S1028455918301839 |
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