MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to promote...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1120533/full |
| _version_ | 1797943835540586496 |
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| author | Yuejun Zheng Yuejun Zheng Zilin Wei Tianhui Wang Tianhui Wang |
| author_facet | Yuejun Zheng Yuejun Zheng Zilin Wei Tianhui Wang Tianhui Wang |
| author_sort | Yuejun Zheng |
| collection | DOAJ |
| description | Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to promote cell balance. Different tissues co-expressed the protein with mitochondria, and plasma also contained the protein, but its level decreased with age. In addition, MOTS-c has been shown to improve glucose metabolism in skeletal muscle, which indicates its benefits for diseases such as diabetes, obesity, and aging. Nevertheless, MOTS-c has been used less frequently in disease treatment, and no effective method of applying MOTS-c in the clinic has been developed. Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived polypeptide MOTS-c, and the application of MOTS-c in the treatment of various diseases, such as aging, cardiovascular disease, insulin resistance, and inflammation. To provide additional ideas for future research and development, we tapped into the molecular mechanisms and therapeutic potentials of MOTS-c to improve diseases and combined the technology with synthetic biology in order to offer a new approach to its development and application. |
| first_indexed | 2024-04-10T20:30:25Z |
| format | Article |
| id | doaj.art-2890e35c75ca43b5afc444e360853c7a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T20:30:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2890e35c75ca43b5afc444e360853c7a2023-01-25T06:43:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011410.3389/fendo.2023.11205331120533MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationYuejun Zheng0Yuejun Zheng1Zilin Wei2Tianhui Wang3Tianhui Wang4Environmental and Operational Medicine Research Department, Academy of Military Medical Sciences, Academy of Military Sciences, Tianjin, ChinaTianjin Key Lab of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin, ChinaEnvironmental and Operational Medicine Research Department, Academy of Military Medical Sciences, Academy of Military Sciences, Tianjin, ChinaEnvironmental and Operational Medicine Research Department, Academy of Military Medical Sciences, Academy of Military Sciences, Tianjin, ChinaTianjin Key Lab of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin, ChinaMitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to promote cell balance. Different tissues co-expressed the protein with mitochondria, and plasma also contained the protein, but its level decreased with age. In addition, MOTS-c has been shown to improve glucose metabolism in skeletal muscle, which indicates its benefits for diseases such as diabetes, obesity, and aging. Nevertheless, MOTS-c has been used less frequently in disease treatment, and no effective method of applying MOTS-c in the clinic has been developed. Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived polypeptide MOTS-c, and the application of MOTS-c in the treatment of various diseases, such as aging, cardiovascular disease, insulin resistance, and inflammation. To provide additional ideas for future research and development, we tapped into the molecular mechanisms and therapeutic potentials of MOTS-c to improve diseases and combined the technology with synthetic biology in order to offer a new approach to its development and application.https://www.frontiersin.org/articles/10.3389/fendo.2023.1120533/fullMOTS-cmitochondrial-derived peptidetherapeutic exploitationsynthetic biologyendocrine |
| spellingShingle | Yuejun Zheng Yuejun Zheng Zilin Wei Tianhui Wang Tianhui Wang MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation Frontiers in Endocrinology MOTS-c mitochondrial-derived peptide therapeutic exploitation synthetic biology endocrine |
| title | MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation |
| title_full | MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation |
| title_fullStr | MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation |
| title_full_unstemmed | MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation |
| title_short | MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation |
| title_sort | mots c a promising mitochondrial derived peptide for therapeutic exploitation |
| topic | MOTS-c mitochondrial-derived peptide therapeutic exploitation synthetic biology endocrine |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1120533/full |
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