Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation
Efforts to find a better adjuvant in regional anaesthesia are underway since long. Aims and objectives are to compare the efficacy and clinical profile of two α-2 adrenergic agonists, dexmedetomidine and clonidine, in epidural anaesthesia with special emphasis on their sedative properties and an abi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=2;spage=116;epage=121;aulast=Bajwa |
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| author | Sukhminder Jit Singh Bajwa Sukhwinder Kaur Bajwa Jasbir Kaur Gurpreet Singh Vikramjit Arora Sachin Gupta Ashish Kulshrestha Amarjit Singh S S Parmar Anita Singh SPS Goraya |
| author_facet | Sukhminder Jit Singh Bajwa Sukhwinder Kaur Bajwa Jasbir Kaur Gurpreet Singh Vikramjit Arora Sachin Gupta Ashish Kulshrestha Amarjit Singh S S Parmar Anita Singh SPS Goraya |
| author_sort | Sukhminder Jit Singh Bajwa |
| collection | DOAJ |
| description | Efforts to find a better adjuvant in regional anaesthesia are underway since long. Aims and objectives are to compare the efficacy and clinical profile of two α-2 adrenergic agonists, dexmedetomidine and clonidine, in epidural anaesthesia with special emphasis on their sedative properties and an ability to provide smooth intra-operative and post-operative analgesia. A prospective randomized study was carried out which included 50 adult female patients between the ages of 44 and 65 years of (American Society of Anaesthesiologists) ASAI/II grade who underwent vaginal hysterectomies. The patients were randomly allocated into two groups; ropivacaine + dexmedetomidine (RD) and ropivacaine + clonidine (RC), comprising of 25 patients each. Group RD was administered 17 ml of 0.75% epidural ropivacaine and 1.5 μg/kg of dexmedetomidine, while group RC received admixture of 17 ml of 0.75% ropivacaine and 2 μg/kg of clonidine. Onset of analgesia, sensory and motor block levels, sedation, duration of analgesia and side effects were observed. The data obtained was subjected to statistical computation with analysis of variance and chi-square test using statistical package for social science (SPSS) version 10.0 for windows and value of P< 0.05 was considered significant and P< 0.0001 as highly significant. The demographic profile, initial and post-operative block characteristics and cardio-respiratory parameters were comparable and statistically non-significant in both the groups. However, sedation scores with dexmedetomidine were better than clonidine and turned out to be statistically significant (P< 0.05). The side effect profile was also comparable with a little higher incidence of nausea and dry mouth in both the groups which was again a non-significant entity (P> 0.05). Dexmedetomidine is a better neuraxial adjuvant compared to clonidine for providing early onset of sensory analgesia, adequate sedation and a prolonged post-operative analgesia. |
| first_indexed | 2024-12-11T08:15:45Z |
| format | Article |
| id | doaj.art-28915e8cac02486589cfb58e54287cc1 |
| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-11T08:15:45Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-28915e8cac02486589cfb58e54287cc12022-12-22T01:14:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492011-01-0155211612110.4103/0019-5049.79883Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluationSukhminder Jit Singh BajwaSukhwinder Kaur BajwaJasbir KaurGurpreet SinghVikramjit AroraSachin GuptaAshish KulshresthaAmarjit SinghS S ParmarAnita SinghSPS GorayaEfforts to find a better adjuvant in regional anaesthesia are underway since long. Aims and objectives are to compare the efficacy and clinical profile of two α-2 adrenergic agonists, dexmedetomidine and clonidine, in epidural anaesthesia with special emphasis on their sedative properties and an ability to provide smooth intra-operative and post-operative analgesia. A prospective randomized study was carried out which included 50 adult female patients between the ages of 44 and 65 years of (American Society of Anaesthesiologists) ASAI/II grade who underwent vaginal hysterectomies. The patients were randomly allocated into two groups; ropivacaine + dexmedetomidine (RD) and ropivacaine + clonidine (RC), comprising of 25 patients each. Group RD was administered 17 ml of 0.75% epidural ropivacaine and 1.5 μg/kg of dexmedetomidine, while group RC received admixture of 17 ml of 0.75% ropivacaine and 2 μg/kg of clonidine. Onset of analgesia, sensory and motor block levels, sedation, duration of analgesia and side effects were observed. The data obtained was subjected to statistical computation with analysis of variance and chi-square test using statistical package for social science (SPSS) version 10.0 for windows and value of P< 0.05 was considered significant and P< 0.0001 as highly significant. The demographic profile, initial and post-operative block characteristics and cardio-respiratory parameters were comparable and statistically non-significant in both the groups. However, sedation scores with dexmedetomidine were better than clonidine and turned out to be statistically significant (P< 0.05). The side effect profile was also comparable with a little higher incidence of nausea and dry mouth in both the groups which was again a non-significant entity (P> 0.05). Dexmedetomidine is a better neuraxial adjuvant compared to clonidine for providing early onset of sensory analgesia, adequate sedation and a prolonged post-operative analgesia.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=2;spage=116;epage=121;aulast=BajwaClonidinedexmedetomidineepidural anaesthesiaropivacainevaginal hysterectomy |
| spellingShingle | Sukhminder Jit Singh Bajwa Sukhwinder Kaur Bajwa Jasbir Kaur Gurpreet Singh Vikramjit Arora Sachin Gupta Ashish Kulshrestha Amarjit Singh S S Parmar Anita Singh SPS Goraya Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation Indian Journal of Anaesthesia Clonidine dexmedetomidine epidural anaesthesia ropivacaine vaginal hysterectomy |
| title | Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation |
| title_full | Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation |
| title_fullStr | Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation |
| title_full_unstemmed | Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation |
| title_short | Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation |
| title_sort | dexmedetomidine and clonidine in epidural anaesthesia a comparative evaluation |
| topic | Clonidine dexmedetomidine epidural anaesthesia ropivacaine vaginal hysterectomy |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=2;spage=116;epage=121;aulast=Bajwa |
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