Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region
ABSTRACTMolecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjecte...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1682472 |
| _version_ | 1797385749291597824 |
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| author | Yun Luo Elaine Cheong Qiao Bian Deirdre A. Collins Julian Ye Jeong Hwan Shin Wing Cheong Yam Tohru Takata Xiaojun Song Xianjun Wang Mini Kamboj Thomas Gottlieb Jianmin Jiang Thomas V. Riley Yi-Wei Tang Dazhi Jin |
| author_facet | Yun Luo Elaine Cheong Qiao Bian Deirdre A. Collins Julian Ye Jeong Hwan Shin Wing Cheong Yam Tohru Takata Xiaojun Song Xianjun Wang Mini Kamboj Thomas Gottlieb Jianmin Jiang Thomas V. Riley Yi-Wei Tang Dazhi Jin |
| author_sort | Yun Luo |
| collection | DOAJ |
| description | ABSTRACTMolecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence typing (ST) and antimicrobial susceptibility testing. Totally, 394 isolates were collected from Hangzhou, Hong Kong, China; Busan, South Korea; Fukuoka, Japan; Singapore; Perth, Sydney, Australia; New York, the United States. C. difficile isolates included 337 toxin A-positive/B-positive/binary toxin-negative (A+B+CDT-), 48 A-B+CDT-, and nine A+B+CDT+. Distribution of dominant STs varied geographically with ST17 in Fukuoka (18.6%), Busan (56.0%), ST2 in Sydney (20.4%), Perth (25.8%). The antimicrobial resistance patterns were significantly different among the eight sites (χ2 = 325.64, p < 0.001). Five major clonal complexes correlated with unique antimicrobial resistances. Healthcare-associated (HA) CDI was mainly from older patients with more frequent antimicrobial use and higher A-B+ positive rates. Higher resistance to gatifloxacin, tetracycline, and erythromycin were observed in HA-CDI patients (χ2 = 4.76-7.89, p = 0.005-0.029). In conclusion, multiple C. difficile genotypes with varied antimicrobial resistance patterns have been circulating in the Asia-Pacific region. A-B+ isolates from older patients with prior antimicrobial use were correlated with HA-CDI. |
| first_indexed | 2024-03-08T21:58:45Z |
| format | Article |
| id | doaj.art-2892dcec8a014a0aa37162f118fe650f |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:58:45Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-2892dcec8a014a0aa37162f118fe650f2023-12-19T16:09:58ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811553156210.1080/22221751.2019.1682472Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific regionYun Luo0Elaine Cheong1Qiao Bian2Deirdre A. Collins3Julian Ye4Jeong Hwan Shin5Wing Cheong Yam6Tohru Takata7Xiaojun Song8Xianjun Wang9Mini Kamboj10Thomas Gottlieb11Jianmin Jiang12Thomas V. Riley13Yi-Wei Tang14Dazhi Jin15Department of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaDepartment of Infectious Diseases & Microbiology, Concord Repatriation General Hospital, Concord, AustraliaSchool of Medicine, Ningbo University, Ningbo, People’s Republic of ChinaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, AustraliaDepartment of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaDepartment of Laboratory Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of KoreaDepartment of Microbiology, Queen Mary Hospital, Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Infection Control, Fukuoka University Hospital, Fukuoka, JapanCentre of Laboratory Medicine, Zhejiang Provincial People Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, People’s Republic of ChinaDepartment of Laboratory Medicine, Hangzhou First People’s Hospital, Hangzhou, People’s Republic of ChinaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Infectious Diseases & Microbiology, Concord Repatriation General Hospital, Concord, AustraliaDepartment of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, AustraliaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaABSTRACTMolecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence typing (ST) and antimicrobial susceptibility testing. Totally, 394 isolates were collected from Hangzhou, Hong Kong, China; Busan, South Korea; Fukuoka, Japan; Singapore; Perth, Sydney, Australia; New York, the United States. C. difficile isolates included 337 toxin A-positive/B-positive/binary toxin-negative (A+B+CDT-), 48 A-B+CDT-, and nine A+B+CDT+. Distribution of dominant STs varied geographically with ST17 in Fukuoka (18.6%), Busan (56.0%), ST2 in Sydney (20.4%), Perth (25.8%). The antimicrobial resistance patterns were significantly different among the eight sites (χ2 = 325.64, p < 0.001). Five major clonal complexes correlated with unique antimicrobial resistances. Healthcare-associated (HA) CDI was mainly from older patients with more frequent antimicrobial use and higher A-B+ positive rates. Higher resistance to gatifloxacin, tetracycline, and erythromycin were observed in HA-CDI patients (χ2 = 4.76-7.89, p = 0.005-0.029). In conclusion, multiple C. difficile genotypes with varied antimicrobial resistance patterns have been circulating in the Asia-Pacific region. A-B+ isolates from older patients with prior antimicrobial use were correlated with HA-CDI.https://www.tandfonline.com/doi/10.1080/22221751.2019.1682472Clostridium difficilemolecular characteristicsantimicrobial resistanceAsia-Pacific regionhealthcare-associated CDI |
| spellingShingle | Yun Luo Elaine Cheong Qiao Bian Deirdre A. Collins Julian Ye Jeong Hwan Shin Wing Cheong Yam Tohru Takata Xiaojun Song Xianjun Wang Mini Kamboj Thomas Gottlieb Jianmin Jiang Thomas V. Riley Yi-Wei Tang Dazhi Jin Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region Emerging Microbes and Infections Clostridium difficile molecular characteristics antimicrobial resistance Asia-Pacific region healthcare-associated CDI |
| title | Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region |
| title_full | Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region |
| title_fullStr | Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region |
| title_full_unstemmed | Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region |
| title_short | Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region |
| title_sort | different molecular characteristics and antimicrobial resistance profiles of clostridium difficile in the asia pacific region |
| topic | Clostridium difficile molecular characteristics antimicrobial resistance Asia-Pacific region healthcare-associated CDI |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1682472 |
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