Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleotides in segment 5 showed comparable attenuation i...

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Bibliographic Details
Main Authors: Eleanor Gaunt, Helen M Wise, Huayu Zhang, Lian N Lee, Nicky J Atkinson, Marlynne Quigg Nicol, Andrew J Highton, Paul Klenerman, Philippa M Beard, Bernadette M Dutia, Paul Digard, Peter Simmonds
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
Influenza A virus
CpG dinucleotide
vaccine
UpA dinucleotide
immunization
Online Access:https://elifesciences.org/articles/12735

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