EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD)
Gender differences can significantly affect mortality in ST-segment elevation myocardial infarction (STEMI) in real practice. Aim. To evaluate the effect of gender on mortality in STEMI. Material and methods. Outcomes of in-hospital stage of treatment of 553 men (67.7%) and 263 women (32.3%) were an...
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| Format: | Article |
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Столичная издательская компания
2016-06-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1272 |
| _version_ | 1797232212435795968 |
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| author | D. B. Nemik G. V. Matyushin A. V. Protopopov A. V. Shulmin S. A. Ustyugov |
| author_facet | D. B. Nemik G. V. Matyushin A. V. Protopopov A. V. Shulmin S. A. Ustyugov |
| author_sort | D. B. Nemik |
| collection | DOAJ |
| description | Gender differences can significantly affect mortality in ST-segment elevation myocardial infarction (STEMI) in real practice. Aim. To evaluate the effect of gender on mortality in STEMI. Material and methods. Outcomes of in-hospital stage of treatment of 553 men (67.7%) and 263 women (32.3%) were analyzed in single-center retrospective study. Primary percutaneous coronary intervention (pPCI) and pharmacoinvasive strategy (PIS) were used in 160 (60.8%) and 103 (39.2%) women, respectively, as well as in 295 (53.3%) and 258 (46.7%) men, respectively. Patients with time ″primary medical contact (PMC) – balloon″ less than 60 min and ″symptom - PMC″ more than 6 hours were excluded. The majority of patients were in a time interval ″PMC - balloon″ about 120 minutes. Results. Mortality in women was significantly higher than this in men regardless of the reperfusion strategy – 15.3% in whole (18.1% at pPCI and 10.9% at PIS), and 3.1% in whole (5.1% at pPCI and 0.8% at FIS), respectively (p<0.001). The probability of lethal outcome in women was 4 times higher than this in men (odds ratio 4.4; 95% confidence interval 2.7-7.1). Conclusion. Clinical characteristics of the patients due to gender differences make a significant contribution to the course of STEMI. Women more often have severe complications and a worse in-hospital prognosis. |
| first_indexed | 2024-03-08T14:02:48Z |
| format | Article |
| id | doaj.art-2895cdda521b40968ddadf93482d1f28 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:56:41Z |
| publishDate | 2016-06-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-2895cdda521b40968ddadf93482d1f282024-04-01T07:43:33ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-06-0112329630110.20996/1819-6446-2016-12-3-296-3011220EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD)D. B. Nemik0G. V. Matyushin1A. V. Protopopov2A. V. Shulmin3S. A. Ustyugov4Krasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia Krasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia Krasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 RussiaKrasnoyarsk State Medical University named after Professor. V.F. Voino-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaKrasnoyarsk Regional Clinical Hospital. Partizana Zheleznyaka ul. 3a, Krasnoyarsk, 660022 RussiaGender differences can significantly affect mortality in ST-segment elevation myocardial infarction (STEMI) in real practice. Aim. To evaluate the effect of gender on mortality in STEMI. Material and methods. Outcomes of in-hospital stage of treatment of 553 men (67.7%) and 263 women (32.3%) were analyzed in single-center retrospective study. Primary percutaneous coronary intervention (pPCI) and pharmacoinvasive strategy (PIS) were used in 160 (60.8%) and 103 (39.2%) women, respectively, as well as in 295 (53.3%) and 258 (46.7%) men, respectively. Patients with time ″primary medical contact (PMC) – balloon″ less than 60 min and ″symptom - PMC″ more than 6 hours were excluded. The majority of patients were in a time interval ″PMC - balloon″ about 120 minutes. Results. Mortality in women was significantly higher than this in men regardless of the reperfusion strategy – 15.3% in whole (18.1% at pPCI and 10.9% at PIS), and 3.1% in whole (5.1% at pPCI and 0.8% at FIS), respectively (p<0.001). The probability of lethal outcome in women was 4 times higher than this in men (odds ratio 4.4; 95% confidence interval 2.7-7.1). Conclusion. Clinical characteristics of the patients due to gender differences make a significant contribution to the course of STEMI. Women more often have severe complications and a worse in-hospital prognosis.https://www.rpcardio.online/jour/article/view/1272thrombolytic therapyst-segment elevation myocardial infarctionpercutaneous coronary interventionpharmacoinvasive strategygender |
| spellingShingle | D. B. Nemik G. V. Matyushin A. V. Protopopov A. V. Shulmin S. A. Ustyugov EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) Рациональная фармакотерапия в кардиологии thrombolytic therapy st-segment elevation myocardial infarction percutaneous coronary intervention pharmacoinvasive strategy gender |
| title | EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) |
| title_full | EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) |
| title_fullStr | EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) |
| title_full_unstemmed | EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) |
| title_short | EFFECT OF GENDER DIFFERENCES ON THE EFFICACY AND SAFETY OF REPERFUSION THERAPY OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (DATA OF RETROSPECTIVE SINGLE-CENTER STUDY – HOSPITAL PERIOD) |
| title_sort | effect of gender differences on the efficacy and safety of reperfusion therapy of st segment elevation myocardial infarction data of retrospective single center study hospital period |
| topic | thrombolytic therapy st-segment elevation myocardial infarction percutaneous coronary intervention pharmacoinvasive strategy gender |
| url | https://www.rpcardio.online/jour/article/view/1272 |
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