Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients
Background: The burn is an injury consisting of the destruction of the skin and the underlying tissues. The neopterin(Neo) is produced by activated macrophages, in response to interferon-gamma derived from activated T cell. Interleukin1 beta (IL-1β) is an important mediator of the inflammatory resp...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of medicine/ University of Diyala
2019-04-01
|
| Series: | Diyala Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/215 |
| _version_ | 1827731054530658304 |
|---|---|
| author | Ruqaya M Al-Barzinji Amer A Khaleel |
| author_facet | Ruqaya M Al-Barzinji Amer A Khaleel |
| author_sort | Ruqaya M Al-Barzinji |
| collection | DOAJ |
| description |
Background: The burn is an injury consisting of the destruction of the skin and the underlying tissues. The neopterin(Neo) is produced by activated macrophages, in response to interferon-gamma derived from activated T cell. Interleukin1 beta (IL-1β) is an important mediator of the inflammatory response.
Objective: Estimation of Neo and IL-1β in burned patients to determine the changes in these parameters in relation to percentage of total burn body surface area (TBSA%) and the duration of hospital stay.
Patients and Methods: Fifty burned patients who were admitted to West Erbil Emergency Hospital in Erbil governorate were included. Out of 50 burnt patients 20 patients were secondly sampled to follow-up serum levels for Neo and IL- β. The burn patients in this study was divided into four groups according to the TBSA%.
Results: Comparing mean concentration of serum Neo and IL-1β in burn patients and healthy control revealed increased levels of Neo and IL-1β in burnt patients with increased TBSA% , indeed IL-1β serum level also increased in non-survivor burn patients compared with survivor patients and HC. Indeed levels of Neo level increased significantly in (10) day post burn.
Conclusion: Levels of Neo and IL-1β increased in burnt patients with increased TBSA%, non-survivor compared with survivor patients and HC. Indeed levels of Neo level increased in (10) day post burn.
|
| first_indexed | 2024-03-11T00:21:17Z |
| format | Article |
| id | doaj.art-2896092a5372433d89fe7b5647ff9240 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-11T00:21:17Z |
| publishDate | 2019-04-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-2896092a5372433d89fe7b5647ff92402023-11-18T23:17:49ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-04-01112Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn PatientsRuqaya M Al-BarzinjiAmer A Khaleel Background: The burn is an injury consisting of the destruction of the skin and the underlying tissues. The neopterin(Neo) is produced by activated macrophages, in response to interferon-gamma derived from activated T cell. Interleukin1 beta (IL-1β) is an important mediator of the inflammatory response. Objective: Estimation of Neo and IL-1β in burned patients to determine the changes in these parameters in relation to percentage of total burn body surface area (TBSA%) and the duration of hospital stay. Patients and Methods: Fifty burned patients who were admitted to West Erbil Emergency Hospital in Erbil governorate were included. Out of 50 burnt patients 20 patients were secondly sampled to follow-up serum levels for Neo and IL- β. The burn patients in this study was divided into four groups according to the TBSA%. Results: Comparing mean concentration of serum Neo and IL-1β in burn patients and healthy control revealed increased levels of Neo and IL-1β in burnt patients with increased TBSA% , indeed IL-1β serum level also increased in non-survivor burn patients compared with survivor patients and HC. Indeed levels of Neo level increased significantly in (10) day post burn. Conclusion: Levels of Neo and IL-1β increased in burnt patients with increased TBSA%, non-survivor compared with survivor patients and HC. Indeed levels of Neo level increased in (10) day post burn. https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/215Neopterin, Interleukin1 beta , total body surface area, burn patients |
| spellingShingle | Ruqaya M Al-Barzinji Amer A Khaleel Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients Diyala Journal of Medicine Neopterin, Interleukin1 beta , total body surface area, burn patients |
| title | Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients |
| title_full | Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients |
| title_fullStr | Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients |
| title_full_unstemmed | Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients |
| title_short | Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients |
| title_sort | assessment of neopterin and interleukin 1 beta serum levels in burn patients |
| topic | Neopterin, Interleukin1 beta , total body surface area, burn patients |
| url | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/215 |
| work_keys_str_mv | AT ruqayamalbarzinji assessmentofneopterinandinterleukin1betaserumlevelsinburnpatients AT amerakhaleel assessmentofneopterinandinterleukin1betaserumlevelsinburnpatients |