Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration
Hydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/12/6203 |
| _version_ | 1797530850942779392 |
|---|---|
| author | Elham Pishavar Hongrong Luo Mahshid Naserifar Maryam Hashemi Shirin Toosi Anthony Atala Seeram Ramakrishna Javad Behravan |
| author_facet | Elham Pishavar Hongrong Luo Mahshid Naserifar Maryam Hashemi Shirin Toosi Anthony Atala Seeram Ramakrishna Javad Behravan |
| author_sort | Elham Pishavar |
| collection | DOAJ |
| description | Hydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different human diseases. Recent progress in cell-free bone tissue engineering via combining exosomes obtained from human mesenchymal stem cells (MSCs) with hydrogel scaffolds has resulted in improvement of the methodologies in bone tissue engineering. Our research has been actively focused on application of biotechnological methods for improving osteogenesis and bone healing. The following text presents a concise review of the methodologies of fabrication and preparation of hydrogels that includes the exosome loading properties of hydrogels for bone regenerative applications. |
| first_indexed | 2024-03-10T10:35:52Z |
| format | Article |
| id | doaj.art-2896a5e3dfae434ab4c245ab18aa29e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:35:52Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2896a5e3dfae434ab4c245ab18aa29e32023-11-21T23:19:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212620310.3390/ijms22126203Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone RegenerationElham Pishavar0Hongrong Luo1Mahshid Naserifar2Maryam Hashemi3Shirin Toosi4Anthony Atala5Seeram Ramakrishna6Javad Behravan7Biotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, IranEngineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, ChinaBiotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, IranBiotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, IranBiotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, IranWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USACenter for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore 117581, SingaporeBiotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, IranHydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different human diseases. Recent progress in cell-free bone tissue engineering via combining exosomes obtained from human mesenchymal stem cells (MSCs) with hydrogel scaffolds has resulted in improvement of the methodologies in bone tissue engineering. Our research has been actively focused on application of biotechnological methods for improving osteogenesis and bone healing. The following text presents a concise review of the methodologies of fabrication and preparation of hydrogels that includes the exosome loading properties of hydrogels for bone regenerative applications.https://www.mdpi.com/1422-0067/22/12/6203bone tissue engineeringexosomeadvanced hydrogels |
| spellingShingle | Elham Pishavar Hongrong Luo Mahshid Naserifar Maryam Hashemi Shirin Toosi Anthony Atala Seeram Ramakrishna Javad Behravan Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration International Journal of Molecular Sciences bone tissue engineering exosome advanced hydrogels |
| title | Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration |
| title_full | Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration |
| title_fullStr | Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration |
| title_full_unstemmed | Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration |
| title_short | Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration |
| title_sort | advanced hydrogels as exosome delivery systems for osteogenic differentiation of mscs application in bone regeneration |
| topic | bone tissue engineering exosome advanced hydrogels |
| url | https://www.mdpi.com/1422-0067/22/12/6203 |
| work_keys_str_mv | AT elhampishavar advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT hongrongluo advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT mahshidnaserifar advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT maryamhashemi advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT shirintoosi advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT anthonyatala advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT seeramramakrishna advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration AT javadbehravan advancedhydrogelsasexosomedeliverysystemsforosteogenicdifferentiationofmscsapplicationinboneregeneration |