An unexpected effect of TNF-α on F508del-CFTR maturation and function [v2; ref status: indexed, http://f1000r.es/5tv]

An unexpected effect of TNF-α on F508del-CFTR maturation and function [v2; ref status: indexed, http://f1000r.es/5tv]

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which encodes a cAMP-dependent Cl- channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially function...

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Bibliographic Details
Main Authors: Sara Bitam, Iwona Pranke, Monika Hollenhorst, Nathalie Servel, Christelle Moquereau, Danielle Tondelier, Aurélie Hatton, Valérie Urbach, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Aleksander Edelman
Format: Article
Language:English
Published: F1000 Research Ltd 2015-09-01
Series:F1000Research
Subjects:
Cell Signaling
Control of Gene Expression
Genomics
Online Access:http://f1000research.com/articles/4-218/v2

Internet

http://f1000research.com/articles/4-218/v2

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